Title:
CULTURE MEDIUM FOR EXPANSION CULTURE OF NEPHRON PROGENITOR CELL, METHOD FOR PERFORMING EXPANSION CULTURE OF NEPHRON PROGENITOR CELL, AND METHOD FOR PRODUCING KIDNEY ORGANOID
Document Type and Number:
WIPO Patent Application WO/2022/149615
Kind Code:
A1
Abstract:
This culture medium is one for performing the expansion culture of a nephron progenitor cell, and contains at least one component selected from the group consisting of a TBK1 inhibitor, a CSF1R inhibitor, an FLT3 inhibitor, a DYRK1 inhibitor and an STAT6 inhibitor.
Inventors:
OSAFUNE KENJI (JP)
ARAOKA TOSHIKAZU (JP)
INOUE TATSUYUKI (JP)
ARAOKA TOSHIKAZU (JP)
INOUE TATSUYUKI (JP)
Application Number:
PCT/JP2022/000539
Publication Date:
July 14, 2022
Filing Date:
January 11, 2022
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/077; C12N5/10
Domestic Patent References:
| WO2017010448A1 | 2017-01-19 | |||
| WO2020213734A1 | 2020-10-22 | |||
| WO2018216743A1 | 2018-11-29 | |||
| WO2021125340A1 | 2021-06-24 |
Foreign References:
| US20150275168A1 | 2015-10-01 | |||
| US20170205396A1 | 2017-07-20 |
Other References:
TSUJIMOTO HIRAKU; ARAOKA TOSHIKAZU; NISHI YOHEI; OHTA AKIRA; NAKAHATA TATSUTOSHI; OSAFUNE KENJI: "Small molecule TCS21311 can replace BMP7 and facilitate cell proliferation in in vitro expansion culture of nephron progenitor cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 558, 26 February 2020 (2020-02-26), Amsterdam NL , pages 231 - 238, XP086572913, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2020.02.130
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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