CUSTOM LIGAND DESIGN FOR BIOMOLECULAR FILTRATION AND PURIFICATION FOR BIOSEPERATION

Title:

CUSTOM LIGAND DESIGN FOR BIOMOLECULAR FILTRATION AND PURIFICATION FOR BIOSEPERATION

Document Type and Number:

WIPO Patent Application WO2003072054

Kind Code:

A3

Abstract:

The instant invention relates to a method of isolating a bio-active molecule of interest from a biological system using affinity separation. The affinity separation ligand for the bio-active molecule of interest is selected by directed molecular evolution to customize the properties of the interaction between the bio-active molecule of interest and the affinity separation ligand thereby facilitating isolation of the bio-active molecule of interest. The invention also relates to compositions comprising an affinity separation ligand bound to a solid support wherein the separation ligand is selected by the method of directed molecular evolution.

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Inventors:

AFFHOLTER JOSEPH A

Application Number:

PCT/US2003/005732

Publication Date:

April 29, 2004

Filing Date:

February 25, 2003

Export Citation:

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Assignee:

CABOT CORP (US)

International Classes:

C07K1/22; C12N15/10; G01N33/53; G01N33/543; (IPC1-7): G01N33/53

Foreign References:

US5658727A	1997-08-19
US6171820B1	2001-01-09

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