Title:
CXCR3 LIGAND
Document Type and Number:
WIPO Patent Application WO/2020/116498
Kind Code:
A1
Abstract:
The present disclosure relates to a CXCR3 ligand having DPPIV resistance and CXCR3-expressing cell migration activity, and specifically relates to the N-terminal amino acid modification and the N-terminal amino acid sequence that are important for DPPIV resistance and CXCR3-expressing cell migration activity.
Inventors:
YAMAMOTO YOHEI (JP)
SAKURAI MIKA (JP)
HARAYA KENTA (JP)
SAKURAI MIKA (JP)
HARAYA KENTA (JP)
Application Number:
PCT/JP2019/047382
Publication Date:
June 11, 2020
Filing Date:
December 04, 2019
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61P29/00; A61K38/17; A61K47/68; A61P37/02; A61P43/00; C07K14/52; C07K19/00; C12N15/19; C12P21/00
Domestic Patent References:
| WO2003082335A1 | 2003-10-09 | |||
| WO2018097308A1 | 2018-05-31 |
Foreign References:
| US6562347B1 | 2003-05-13 | |||
| US6534626B1 | 2003-03-18 | |||
| JP2007525188A | 2007-09-06 |
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KIESEIER ET AL., BRAIN, vol. 125, 2002, pages 823 - 34
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GAZITT, Y., J. HEMATOTHER STEM CELL RES, vol. 10, 2001, pages 229 - 36
HATTORI ET AL., BLOOD, vol. 97, 2001, pages 3354 - 59
NOMURA ET AL., INT. J. CANCER, vol. 91, 2001, pages 597 - 606
MACHDRANOFF, CURR. OPIN. IMMUNOL., vol. 12, 2000, pages 571 - 75
PAUL D. PONATH ET AL., METHODS IN MOLECULAR BIOLOGY, vol. 138, 2000, pages 113 - 120
BOOTH V ET AL., BIOCHEMISTRY, vol. 41, no. 33, 2002, pages 10418 - 10425
RANI MR, THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 19, 9 May 2003 (2003-05-09), pages 17066 - 17074
PROC. NATL. ACAD. SCI. USA, vol. 103, no. 11, 2006, pages 4005 - 4010
MOLECULAR AND CELLULAR BIOLOGY, August 2006 (2006-08-01), pages 5838 - 5849
METHODS ENZYMOL., vol. 323, 2000, pages 325 - 40
MOLECULAR AND CELLULAR BIOLOGY, vol. 26, no. 15, August 2006 (2006-08-01), pages 5838 - 5849
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
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MOL CELL BIOL., vol. 8, 1988, pages 466 - 472
"Current protocols in Molecular Biology", 1987, JOHN WILEY & SONS
"Uniprot", Database accession no. P02778
See also references of EP 3892330A4
WANG P, CANCER IMMUNOL IMMUNOTHER, vol. 59, no. 11, November 2010 (2010-11-01), pages 1715 - 26
DECALF J, EMBO MOL MED, vol. 8, no. 6, 1 June 2016 (2016-06-01), pages 679 - 83
RAINCZUK A, INT J CANCER, vol. 134, no. 3, 1 February 2014 (2014-02-01), pages 530 - 41
BOOTH V, BIOCHEMISTRY, vol. 41, no. 33, 20 August 2002 (2002-08-20), pages 10418 - 25
SWAMINATHAN GJ, STRUCTURE, vol. 11, no. 5, May 2003 (2003-05-01), pages 521 - 32
TROTTA T, MOL IMMUNOL, vol. 47, no. 2-3, December 2009 (2009-12-01), pages 332 - 9
COLE KE., THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 12, pages 2009 - 21
TENSEN CP, THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 112, no. 5, pages 716 - 22
KUNKEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
ANNU. REV. BIOPHYS. BIOMOL. STRUCT., vol. 35, 2006, pages 225 - 249
PROC. NATL. ACAD. SCI. U.S.A., vol. 100, no. 11, 2003, pages 6353 - 6357
CLARK-LEWIS ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 16075 - 16081
BELPERIO ET AL., J. LEUKOC. BIOL., vol. 68, 2000, pages 1 - 8
DUFOUR ET AL., J IMMUNOL., vol. 168, 2002, pages 3195 - 204
KIESEIER ET AL., BRAIN, vol. 125, 2002, pages 823 - 34
NAGASAWA, T., INT. J. HEMATOL., vol. 72, 2000, pages 408 - 11
GAZITT, Y., J. HEMATOTHER STEM CELL RES, vol. 10, 2001, pages 229 - 36
HATTORI ET AL., BLOOD, vol. 97, 2001, pages 3354 - 59
NOMURA ET AL., INT. J. CANCER, vol. 91, 2001, pages 597 - 606
MACHDRANOFF, CURR. OPIN. IMMUNOL., vol. 12, 2000, pages 571 - 75
PAUL D. PONATH ET AL., METHODS IN MOLECULAR BIOLOGY, vol. 138, 2000, pages 113 - 120
BOOTH V ET AL., BIOCHEMISTRY, vol. 41, no. 33, 2002, pages 10418 - 10425
RANI MR, THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 19, 9 May 2003 (2003-05-09), pages 17066 - 17074
PROC. NATL. ACAD. SCI. USA, vol. 103, no. 11, 2006, pages 4005 - 4010
MOLECULAR AND CELLULAR BIOLOGY, August 2006 (2006-08-01), pages 5838 - 5849
METHODS ENZYMOL., vol. 323, 2000, pages 325 - 40
MOLECULAR AND CELLULAR BIOLOGY, vol. 26, no. 15, August 2006 (2006-08-01), pages 5838 - 5849
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
"GenBank", Database accession no. AB009864
MOL CELL BIOL., vol. 8, 1988, pages 466 - 472
"Current protocols in Molecular Biology", 1987, JOHN WILEY & SONS
"Uniprot", Database accession no. P02778
See also references of EP 3892330A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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