Title:
CYANOTHIOPHENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2016/021562
Kind Code:
A1
Abstract:
The present invention pertains to: a cyanothiophene derivative represented by formula (I), exhibiting NK1 receptor antagonist activity, and useful in the prevention or treatment of the nausea and vomiting which accompanies the administration of antineoplastic agents; or a pharmaceutically acceptable salt thereof. In the formula, R1a represents an alkyl or the like, R1b represents a halogen atom or the like, R2 represents an alkyl or the like, R3a and R3b represent an alkyl or the like, R4a, R4b and R4c represent a hydrogen atom or a haloalkyl or the like, ring A represents a heterocycloalkyl or the like, U1 and U2 represent a single bond or an alkylene or the like, V represents a single bond or an alkylene or the like, and R5 represents a carboxy or an acyl or the like.
Inventors:
UENO YASUNORI (JP)
OHNO KOHSUKE (JP)
MIYAGI TAKASHI (JP)
SHIMIZU KAZUO (JP)
ONDA YUSUKE (JP)
SUZUKI HIKARU (JP)
OHNO KOHSUKE (JP)
MIYAGI TAKASHI (JP)
SHIMIZU KAZUO (JP)
ONDA YUSUKE (JP)
SUZUKI HIKARU (JP)
Application Number:
PCT/JP2015/071993
Publication Date:
February 11, 2016
Filing Date:
August 03, 2015
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
International Classes:
C07D409/06; A61K31/381; A61K31/397; A61K31/4025; A61K31/4535; A61K31/496; A61K31/5377; A61K31/5386; A61K31/541; A61K31/55; A61K31/551; A61P1/08; C07D413/06; C07D487/04; C07D491/08
Domestic Patent References:
| WO2011138916A1 | 2011-11-10 | |||
| WO2008128891A1 | 2008-10-30 | |||
| WO2011131571A1 | 2011-10-27 | |||
| WO2006060390A1 | 2006-06-08 | |||
| WO2000073278A2 | 2000-12-07 | |||
| WO2011054773A1 | 2011-05-12 | |||
| WO2009138393A1 | 2009-11-19 | |||
| WO2007028654A1 | 2007-03-15 | |||
| WO2015024203A1 | 2015-02-26 | |||
| WO2015068744A1 | 2015-05-14 |
Foreign References:
| JP2007277231A | 2007-10-25 |
Attorney, Agent or Firm:
YANAGI, Nobuko et al. (JP)
Willow Nobuko (JP)
Willow Nobuko (JP)
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