Title:
CYCLIC PEPTIDE, SALT OF CYCLIC PEPTIDE, PHARMACEUTICAL COMPOSITION, AND BIOLOGICAL TISSUE CALCIFICATION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/032726
Kind Code:
A1
Abstract:
This cyclic peptide or salt thereof comprises either the amino acid sequence indicated in SEQ ID NO: 1, or an amino acid sequence obtained by deleting or substituting the amino acid of the N-terminus and/or the amino acid of the C-terminus in that amino acid sequence, at least two of the three serine residues corresponding to serine residues #2, #4, and #6 from the N-terminus in the amino acid sequence indicated in SEQ ID NO: 1 having been phosphorylated. The cyclic peptide or salt thereof has the effect of inhibiting biological tissue calcification.
Inventors:
YOSHIKO YUJI (JP)
MINAMIZAKI TOMOKO (JP)
KOHNO SHOHEI (JP)
KHARAGHANI DAVOOD (JP)
YOSHIMORI ATSUSHI (JP)
MINAMIZAKI TOMOKO (JP)
KOHNO SHOHEI (JP)
KHARAGHANI DAVOOD (JP)
YOSHIMORI ATSUSHI (JP)
Application Number:
PCT/JP2022/031496
Publication Date:
March 09, 2023
Filing Date:
August 22, 2022
Export Citation:
Assignee:
UNIV HIROSHIMA (JP)
International Classes:
C07K7/06; A61K38/08; A61K38/12; A61P1/02; A61P19/00; A61P43/00; C07K5/12; C12N15/09
Foreign References:
| JP2013014566A | 2013-01-24 |
Other References:
MINAMIZAKI TOMOKO; SAKURAI KAORU; HAYASHI IKUE; TOSHISHIGE MASAAKI; YOSHIOKA HIROTAKA; KOZAI KATSUYUKI; YOSHIKO YUJI: "Active sites of human MEPE-ASARM regulating bone matrix mineralization", MOLECULAR AND CELLULAR ENDOCRINOLOGY, ELSEVIER IRELAND LTD, IE, vol. 517, 24 July 2020 (2020-07-24), IE , XP086289171, ISSN: 0303-7207, DOI: 10.1016/j.mce.2020.110931
Attorney, Agent or Firm:
KIMURA Mitsuru (JP)
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