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Title:
CYCLOHEXANE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISM
Document Type and Number:
WIPO Patent Application WO/2010/101247
Kind Code:
A1
Abstract:
Disclosed is a novel cyclohexane derivative having NPY Y5 receptor antagonism. Specifically disclosed is a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same. In formula (I), A represents substituted or unsubstituted aryl or heterocyclyl; X and Y are a combination selected from (X,Y)=(C(=O)N(R1), C(=O)N(R2)), (C(=O)N(R1), imidazol-1,3-diyl), (N(R1), C(=O)N(R2)), (O, C(=O)N(R2)), (C(R3)(R4), N(R2)) and (a single bond, C(=O)N(R2)) [wherein R1, R2 and R3 independently represent each hydrogen or substituted or unsubstituted alkyl]; R5 represents substituted or unsubstituted aryl or heterocyclyl; R6 represents halogen, oxo, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy or the like; m represents 0 or 1; n represents an integer of 0 to 5; and B represents an aromatic carbon ring, a monocyclic heterocycle or a bicyclic fused heterocycle.

Inventors:
YOSHIDA HIROSHI (JP)
TONOGAKI KEISUKE (JP)
SAKAGAMI MASAHIRO (JP)
TAKAYA KENJI (JP)
Application Number:
PCT/JP2010/053663
Publication Date:
September 10, 2010
Filing Date:
March 05, 2010
Export Citation:
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Assignee:
SHIONOGI & CO (JP)
YOSHIDA HIROSHI (JP)
TONOGAKI KEISUKE (JP)
SAKAGAMI MASAHIRO (JP)
TAKAYA KENJI (JP)
International Classes:
C07C237/24; A61K31/167; A61K31/275; A61K31/415; A61K31/4184; A61K31/4192; A61K31/42; A61K31/421; A61K31/422; A61K31/423; A61K31/427; A61K31/4375; A61K31/44; A61K31/4439; A61K31/4709; A61K31/4965; A61K31/497; A61K31/5375; A61K31/5377; A61P3/04; A61P43/00; C07C255/54; C07D213/64; C07D213/74; C07D213/81; C07D213/84; C07D231/38; C07D241/18; C07D249/06; C07D261/18; C07D263/34; C07D263/58; C07D265/30; C07D401/12; C07D413/12; C07D417/12; C07D471/04
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Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (JP)
Mitsuo Tanaka (JP)
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