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Title:
PIPERIDINE AND PYRROLIDINE DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISM
Document Type and Number:
WIPO Patent Application WO/2010/101246
Kind Code:
A1
Abstract:
Disclosed are novel piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism. Specifically disclosed are a compound represented by formula (I), a pharmaceutically acceptable salt of the same or a solvate thereof. In formula (I), A represents substituted or unsubstituted monocyclic aryl or monocyclic heterocyclyl; X represents a single bond or C(=O); Y represents a single bond, CR5R6NR7 or C(=O)NR7; R1 and R2 independently represent each hydrogen or substituted or unsubstituted alkyl; R3 represents substituted or unsubstituted aryl or heterocyclyl; R4 represents halogen, substituted or unsubstituted alkyl, alkoxy, aryloxy or heterocyclyloxy, etc.; p represents an integer of 0 to 2; q represents 0 or 1; m represents 0 or 1; n represents an integer of 0 to 5; and B represents an aromatic carbon ring, a monocyclic hetero ring or a dicyclic fused hetero ring.

Inventors:
SAKAGAMI MASAHIRO (JP)
ARAKI HITOMI (JP)
HASHIZUME HIROSHI (JP)
YARI HIROSHI (JP)
TAKAYA KENJI (JP)
Application Number:
PCT/JP2010/053662
Publication Date:
September 10, 2010
Filing Date:
March 05, 2010
Export Citation:
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Assignee:
SHIONOGI & CO (JP)
SAKAGAMI MASAHIRO (JP)
ARAKI HITOMI (JP)
HASHIZUME HIROSHI (JP)
YARI HIROSHI (JP)
TAKAYA KENJI (JP)
International Classes:
C07D207/16; A61K31/40; A61K31/4155; A61K31/445; A61K31/4525; A61K31/454; A61K31/4545; A61K31/506; A61K31/5377; A61P3/04; A61P43/00; C07D211/62; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D405/06; C07D413/06; C07D413/12; C07D417/12; C07D471/04
Domestic Patent References:
WO2001037826A12001-05-31
WO2008108958A22008-09-12
WO2008108957A22008-09-12
WO2007146761A22007-12-21
WO2007125952A12007-11-08
WO2007075555A22007-07-05
Foreign References:
JP2008538749A2008-11-06
JP2003517479A2003-05-27
JP2005529866A2005-10-06
JP2002507611A2002-03-12
JP2000510164A2000-08-08
JP2008179612A2008-08-07
JP2008514616A2008-05-08
JP2004529105A2004-09-24
US20090023710A12009-01-22
JP2008546784A2008-12-25
JP2006517563A2006-07-27
JP2005507906A2005-03-24
JP2008504278A2008-02-14
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (JP)
Mitsuo Tanaka (JP)
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