Title:
CYTOTOXIC T-CELL EPITOPE PEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/203577
Kind Code:
A1
Abstract:
The present invention provides a cytotoxic T-cell (cytotoxic T lymphocyte, abbreviated hereinafter as CTL) epitope peptide specific to the Epstein-Barr virus (described hereinafter as EBV), a vaccine for treating or preventing EBV infection or EBV-positive cancer using this peptide, a passive immunotherapeutic agent for EBV, and a method for assaying CTL specific to EBV. The present invention also provides an HLA-A*24:02-restricted epitope peptide comprising an IYTEVRELV sequence (SEQ ID NO: 43) from a cytoskeleton-associated protein (cytoskeleton-associated protein 4: CKAP4 hereinafter, also known as: CLIMP-63, ERGIC-63, P63). The peptide-specific cytotoxic T-cells (CTL hereinafter) can attack malignant tumor cells that express a high level of CKAP4.
Inventors:
LI DONGLIANG (JP)
OTAKA HIRONORI (JP)
NAKANO KAZUE (JP)
TOJI SHINGO (JP)
OTAKA HIRONORI (JP)
NAKANO KAZUE (JP)
TOJI SHINGO (JP)
Application Number:
PCT/JP2015/067469
Publication Date:
December 22, 2016
Filing Date:
June 17, 2015
Export Citation:
Assignee:
MEDICAL & BIOL LAB CO LTD (JP)
International Classes:
C07K7/08; A61K35/15; A61K35/17; A61K39/245; A61P35/00; C07K16/18; C12N15/00; C12Q1/02
Domestic Patent References:
| WO2009105152A2 | 2009-08-27 |
Foreign References:
| JP2007117023A | 2007-05-17 |
Other References:
MURRAY R. J. ET AL.: "Epstein-Barr virus- specific cytotoxic T- cell recognition of transfectants expressing the virus-coded latent membrane protein LMP", J. VIROL., vol. 62, no. 10, 1988, pages 3747 - 55
CHEUNG W. H. ET AL.: "Conjugation of latent membrane protein (LMP)-2 epitope to gold nanoparticles as highly immunogenic multiple antigenic peptides for induction of Epstein- Barr virus-specific cytotoxic T-lymphocyte responses in vitro", BIOCONJUG. CHEM., vol. 20, no. 1, 2009, pages 24 - 31
LI S. X. ET AL.: "Prognostic significance of cytoskeleton-associated membrane protein 4 and its palmitoyl acyltransferase DHHC2 in hepatocellular carcinoma.", CANCER, vol. 120, no. 10, 2014, pages 1520 - 31
BAO Y. N. ET AL.: "Integrating transcriptome profiling and in silico pathway analysis toward reduction of therapeutic dimensionality in nasopharyngeal carcinoma", CANCER RES., vol. 71, no. 8, 2011
CHEUNG W. H. ET AL.: "Conjugation of latent membrane protein (LMP)-2 epitope to gold nanoparticles as highly immunogenic multiple antigenic peptides for induction of Epstein- Barr virus-specific cytotoxic T-lymphocyte responses in vitro", BIOCONJUG. CHEM., vol. 20, no. 1, 2009, pages 24 - 31
LI S. X. ET AL.: "Prognostic significance of cytoskeleton-associated membrane protein 4 and its palmitoyl acyltransferase DHHC2 in hepatocellular carcinoma.", CANCER, vol. 120, no. 10, 2014, pages 1520 - 31
BAO Y. N. ET AL.: "Integrating transcriptome profiling and in silico pathway analysis toward reduction of therapeutic dimensionality in nasopharyngeal carcinoma", CANCER RES., vol. 71, no. 8, 2011
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
Download PDF: