DAAO INHIBITING B?NZISOXAZOLES AND THEIR USE FOR THE TREATMENT OF MENTAL DISORDERS

WIPO Patent Application WO2005089753

A3

The present invention concerns the compounds of formula (I) , the substituents being specified in the description, (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemical Iy isomeric forms thereof , and their use for the manufacture of a medicament for the treatment of mental disorders, preferably schizophrenia.

KENNIS LUDO EDMOND JOSEPHINE (BE)
VANHOOF GRETA CONSTANTIA PETER (BE)
BONGARTZ JEAN-PIERRE ANDRE MAR (BE)
LUYCKX MARCEL GEREBERNUS MARIA (BE)
MINKE WENDA EVELINE (BE)

PCT/EP2005/051105

November 30, 2006

March 11, 2005

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JANSSEN PHARMACEUTICA NV (BE)
KENNIS LUDO EDMOND JOSEPHINE (BE)
VANHOOF GRETA CONSTANTIA PETER (BE)
BONGARTZ JEAN-PIERRE ANDRE MAR (BE)
LUYCKX MARCEL GEREBERNUS MARIA (BE)
MINKE WENDA EVELINE (BE)

A61K31/423; A61P25/18; C07D261/20; C07D413/12

EP0779281A1

1997-06-18

IMAI H ET AL: "A NEW ANTIBIOTIC Y-T0678H PRODUCED BY A CHROMOBACTERIUM SPECIES", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, TOKYO, JP, vol. 36, no. 7, July 1983 (1983-07-01), pages 911 - 912, XP008060752, ISSN: 0021-8820
IMPICCIATORE M ET AL: "BIOLOGICAL PROPERTIES OF 1,2-BENZISOTHIAZOLES PHARMACOLOGICAL CHARACTERISTICS OF 1,2-BENZISOXAZOLIN-3-ONE AND 1,2-BENZISOTHIAZOLIN-3-ONE", January 1972, CHEMICAL ABSTRACTS + INDEXES, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, PAGE(S) 29, ISSN: 0009-2258, XP002010089

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