DAPB GENE-BASED POLYNUCLEOTIDE HAVING PROMOTER ACTIVITY AND USE THEREOF

WIPO Patent Application WO/2022/257757

A1

Disclosed is a mutant of a corynebacterium glutamicum dihydrodipicolinate reductase (dapB) gene promoter. Compared with the promoter of a wild-type dapB gene, the promoter activity of the mutant is significantly improved. Also disclosed are a transcription expression cassette comprising the promoter mutant, a recombinant expression vector, a recombinant host cell, and a method for constructing a promoter mutant, a method for regulating and controlling transcription of a target gene, a method for preparing a protein, and a method for producing a target compound.

SUN JIBIN (CN)
LIU JIAO (CN)
ZHENG PING (CN)
ZHOU WENJUAN (CN)
SUN GUANNAN (CN)
CHEN JIUZHOU (CN)

PCT/CN2022/094734

December 15, 2022

May 24, 2022

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TIANJIN INST IND BIOTECHNOLOGY CAS (CN)

C12N15/113; C12N1/21; C12N15/77; C12P13/08; C12R1/01

CN111850010A	2020-10-30
CN110846312A	2020-02-28
CN102191247A	2011-09-21
US20180362991A1	2018-12-20

DATABASE NUCLEOTIDE 18 April 2005 (2005-04-18), ANONYMOUS : "B.lactofermentum dapA and dapB genes for dihydrodipicolinate synthase and dihydrodipicolinate reductase", XP093013070, retrieved from NCBI Database accession no. Z21502.1
YANG LIYAN, YANG YASHU;YANG XIAOLAN;ZHU MANXI;WANG CHUANGYUN;DENG YAN;ZHAO LI;GUO HONGXIA;ZHANG LIGUANG: "Gene Abundance and Bioinformatics Analysis of the DAPB Gene in Quinoa", MOLECULAR PLANT BREEDING, vol. 19, no. 1, 15 January 2021 (2021-01-15), pages 34 - 40, XP093013078, ISSN: 1672-416X, DOI: 10.13271/j.mpb.019.000034

LINDA LIU & PARTNERS (CN)

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