DENDRIMER-DELIVERED ALPHA-PARTICLE RADIOTHERAPY FOR TREATMENT OF GLIOBLASTOMA AND OTHER CANCERS IN THE BRAIN

Title:

DENDRIMER-DELIVERED ALPHA-PARTICLE RADIOTHERAPY FOR TREATMENT OF GLIOBLASTOMA AND OTHER CANCERS IN THE BRAIN

Document Type and Number:

WIPO Patent Application WO/2024/007034

Kind Code:

A3

Abstract:

Dendrimers radiolabeled with an alpha particle emitter, such as actinium-225 (225Ac), and their use for treating tumors, including glioblastomas, are disclosed.

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Inventors:

SOFOU STAVROULA (US)
RANGARAMANUJAM KANNAN (US)
NAIR RAJIV RANJIT (US)

Application Number:

PCT/US2023/069583

Publication Date:

March 21, 2024

Filing Date:

July 03, 2023

Export Citation:

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Assignee:

UNIV JOHNS HOPKINS (US)

International Classes:

A61K51/06; C08G73/02

Domestic Patent References:

WO2022094327A1	2022-05-05
WO2021243415A1	2021-12-09

Foreign References:

US20220023448A1	2022-01-27
US20220054659A1	2022-02-24
US20160221992A1	2016-08-04

Other References:

WU ET AL.: "METAL-CHELATE-DENDRIMER-ANTIBODY CONSTRUCTS FOR USE IN RADIOIMMUNOTHERAPY AND IMAGING", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 3, 1994, pages 449 - 454, XP026646436, DOI: 10.1016/0960-894X(94)80014-6
LIKO ET AL.: "Dendrimers as Innovative Radiopharmaceuticals in Cancer Radionanotherapy", BIOMA CROMOLECULES, vol. 17, 8 September 2016 (2016-09-08), pages 3103 - 3114, XP055928735, DOI: 10.1021/acs.biomac.6b00929

Attorney, Agent or Firm:

CHILDERS, Jeffrey W. (US)

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