Title:
DENDRITIC CELL, DRUG CONTAINING THE DENDRITIC CELL, THERAPEUTIC METHOD USING THE DENDRITIC CELL AND METHOD OF CULTURING &gammad &dgr T CELL
Document Type and Number:
WIPO Patent Application WO/2006/006638
Kind Code:
A1
Abstract:
It is intended to provide a dendritic cell for effectively activating and/or proliferating &gammad &dgr T cells in vivo and/or in vitro; a drug containing the same; a therapeutic method using the dendritic cell; and a method of culturing &gammad &dgr T cells using the dendritic cell. An immature dendritic cell originating in peripheral monocyte is pulsed with a bisphosphonate-base bone metabolism-improving agent to thereby impart an ability to activate &gammad &dgr T cells. Then it is cultured with cells containing &gammad &dgr T cells to thereby activate and/or proliferate the &gammad &dgr T cells. Thus, &gammad &dgr T cells can be easily proliferated without placing a burden to a patient, which makes it possible to practically carry out an immunological cell therapy with the use of &gammad &dgr T cells.
Inventors:
NIEDA MIE (JP)
ISOGAI MANAMI (JP)
KAKIMI KAZUHIRO (JP)
ISOGAI MANAMI (JP)
KAKIMI KAZUHIRO (JP)
Application Number:
PCT/JP2005/012971
Publication Date:
January 19, 2006
Filing Date:
July 07, 2005
Export Citation:
Assignee:
MEDINET CO LTD (JP)
NIEDA MIE (JP)
ISOGAI MANAMI (JP)
KAKIMI KAZUHIRO (JP)
NIEDA MIE (JP)
ISOGAI MANAMI (JP)
KAKIMI KAZUHIRO (JP)
International Classes:
A61K35/12; A61K35/14; A61K35/15; A61P31/00; A61P35/00; C12N5/0783; C12N5/0784
Foreign References:
| US6821778B1 | 2004-11-23 |
Other References:
MIYAGAWA F. ET AL.: "Essential requirement of antigen presentation by monocyte lineage cells for the activation of primary human gamma delta T cells by aminobisphosphonate antigen", J. IMMUNOL., vol. 166, 2001, pages 5508 - 5514, XP003000482
KUNZMANN V. ET AL.: "Crucial role of monocytes in aminobisphosphonate recognition by gamma delta T cells", BLOOD, vol. 102, no. 11, 16 November 2003 (2003-11-16), pages 39B, XP003000483
TAJIMA K. ET AL.: "Immunomodulatory effects on cyclosporine A on human peripheral blood dendritic cell subsets", IMMUNOLOGY, vol. 108, 2003, pages 321 - 328, XP003000484
VALLADEAU J. ET AL.: "Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis", vol. 167, no. 10, 2001, pages 5767 - 5774, XP003000485
YONEDA T.: "Bisphosphonate no Sayo Mechanism to Potential", IGAKU NO AYUMI, vol. 189, no. 2, 10 April 1999 (1999-04-10), pages 95 - 100, XP003000486
See also references of EP 1788078A4
KUNZMANN V. ET AL.: "Crucial role of monocytes in aminobisphosphonate recognition by gamma delta T cells", BLOOD, vol. 102, no. 11, 16 November 2003 (2003-11-16), pages 39B, XP003000483
TAJIMA K. ET AL.: "Immunomodulatory effects on cyclosporine A on human peripheral blood dendritic cell subsets", IMMUNOLOGY, vol. 108, 2003, pages 321 - 328, XP003000484
VALLADEAU J. ET AL.: "Immature human dendritic cells express asialoglycoprotein receptor isoforms for efficient receptor-mediated endocytosis", vol. 167, no. 10, 2001, pages 5767 - 5774, XP003000485
YONEDA T.: "Bisphosphonate no Sayo Mechanism to Potential", IGAKU NO AYUMI, vol. 189, no. 2, 10 April 1999 (1999-04-10), pages 95 - 100, XP003000486
See also references of EP 1788078A4
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