Title:
DETECTION MATERIAL, PREPARATION METHOD AND APPLICATION OF ANTI-NMDAR AUTOANTIBODY IN HUMAN BODY FLUID
Document Type and Number:
WIPO Patent Application WO/2021/027250
Kind Code:
A1
Abstract:
Provided are a detection material, a preparation method and an application of an anti-NMDAR autoantibody in human body fluid, NMDAR antigen is coated on a carrier film to prepare an anti-NMDAR receptor detection material, a specific NMDAR antibody in human serum and cerebrospinal fluid can bond with the antigen, an alkaline phosphatase substrate-ligand reaction is carried out for color development, a sealing material is added to the color reaction, and it can be directly judged whether the NMDAR antibody is contained in the detection sample by visual observation. The method has the advantages of high sensitivity, simple and convenient operation, rapid detection and the like, and is beneficial to the recognition and diagnosis of anti-NMDAR receptor encephalitis.
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Inventors:
YAN YAPING (CN)
LI YITING (CN)
HAO WENBIN (CN)
LI KE (CN)
LI YITING (CN)
HAO WENBIN (CN)
LI KE (CN)
Application Number:
PCT/CN2020/071289
Publication Date:
February 18, 2021
Filing Date:
January 10, 2020
Export Citation:
Assignee:
SHAANXI MYBIOTECH CO LTD (CN)
International Classes:
C07K14/705; C07K1/14; C12N15/861; G01N33/531; G01N33/564
Domestic Patent References:
| WO2008073984A2 | 2008-06-19 |
Foreign References:
| CN103282776A | 2013-09-04 | |||
| CN107022548A | 2017-08-08 | |||
| CN110606887A | 2019-12-24 | |||
| CN108603885A | 2018-09-28 | |||
| CN104628810A | 2015-05-20 |
Other References:
SONG ZHAOHUI; LIU LEI; WANG RUIJIN; XU CHUNLING; ZHANG SHANCHAO; DAI FEIFEI; GUO JING; WANG JIAWEI: "Study on the clinical detection of anti-NMDA receptor antibodies", 2013 SHANDONG NEUROLOGY ACADEMIC CONFERENCE AND CHINA NEUROIMMUNOLOGY CONGRESS; 2013-09-07, 31 December 2013 (2013-12-31), pages 194, XP009526025
BAO DING, LI WEI, SHI LEMING, LI QUANZHEN: "Expression, purification and immunoreactivity characterization of extracellular antigenic domains of NMDAR1 protein", SHENGWU GONGCHENG XUEBAO = CHINESE JOURNAL OF BIOTECHNOLOGY, ZHONGGUO KEXUEYUAN WEISHENGWU YANJIUSUO, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF MICROBIOLOGY, CN, vol. 33, no. 12, 25 December 2017 (2017-12-25), CN, pages 1979 - 1988, XP055779899, ISSN: 1000-3061, DOI: 10.13345/j.cjb.170422
SHARMA RASHMI, AL-SALEEM FETWEH H., PULIGEDDA RAMA DEVUDU, RATTELLE AMY, LYNCH DAVID R., DESSAIN SCOTT K.: "Membrane-bound and soluble forms of an NMDA receptor extracellular domain retain epitopes targeted in auto-immune encephalitis", BMC BIOTECHNOLOGY, vol. 18, no. 1, 1 December 2018 (2018-12-01), XP055779896, DOI: 10.1186/s12896-018-0450-1
BAO DING, LI WEI, SHI LEMING, LI QUANZHEN: "Expression, purification and immunoreactivity characterization of extracellular antigenic domains of NMDAR1 protein", SHENGWU GONGCHENG XUEBAO = CHINESE JOURNAL OF BIOTECHNOLOGY, ZHONGGUO KEXUEYUAN WEISHENGWU YANJIUSUO, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF MICROBIOLOGY, CN, vol. 33, no. 12, 25 December 2017 (2017-12-25), CN, pages 1979 - 1988, XP055779899, ISSN: 1000-3061, DOI: 10.13345/j.cjb.170422
SHARMA RASHMI, AL-SALEEM FETWEH H., PULIGEDDA RAMA DEVUDU, RATTELLE AMY, LYNCH DAVID R., DESSAIN SCOTT K.: "Membrane-bound and soluble forms of an NMDA receptor extracellular domain retain epitopes targeted in auto-immune encephalitis", BMC BIOTECHNOLOGY, vol. 18, no. 1, 1 December 2018 (2018-12-01), XP055779896, DOI: 10.1186/s12896-018-0450-1
Attorney, Agent or Firm:
HENG TAI INTELLECTUAL PROPERTY AGENCY (CN)
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