Title:
MATERIAL FOR DETECTING ANTI-MOG AUTOANTIBODY IN HUMAN BODY FLUID, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/027251
Kind Code:
A1
Abstract:
Provided are a material for detecting an anti-MOG autoantibody in a human body fluid, a preparation method therefor and the use thereof. An MOG antigen is coated on an NC membrane to prepare a material for detecting an anti-MOG receptor; a specific MOG antibody in human serum and cerebrospinal liquid can bind to the antigen; color development is carried out using an alkaline phosphatase substrate-ligand reaction; and a sealing material is added during the color development reaction, and it is possible to directly judge whether a test sample contains an MOG antibody by means of a visual inspection. The method has the advantages of a high sensitivity, simple operation, rapid detection etc., and contributes to the recognition and diagnosis of anti-MOG receptor encephalitis.
Inventors:
YAN YAPING (CN)
LI PEI (CN)
LI KE (CN)
LI PEI (CN)
LI KE (CN)
Application Number:
PCT/CN2020/071290
Publication Date:
February 18, 2021
Filing Date:
January 10, 2020
Export Citation:
Assignee:
SHAANXI MYBIOTECH CO LTD (CN)
International Classes:
C07K14/47; C07K1/14; C12N15/867; G01N33/531; G01N33/564
Domestic Patent References:
| WO2004034031A2 | 2004-04-22 |
Foreign References:
| CN107299111A | 2017-10-27 | |||
| CN107022548A | 2017-08-08 | |||
| CN107794269A | 2018-03-13 | |||
| CN110606881A | 2019-12-24 | |||
| CN107271680A | 2017-10-20 | |||
| CN101246178A | 2008-08-20 |
Other References:
WATERS, P.J. ET AL.: "A multicenter comparison of MOG-IgG cell-based assays.", NEUROLOGY, vol. 92, no. 11, 12 March 2019 (2019-03-12), pages e1250 - e1255, XP055779998
Attorney, Agent or Firm:
HENG TAI INTELLECTUAL PROPERTY AGENCY (CN)
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