Title:
DETECTION METHOD FOR USE IN DIAGNOSIS OF POLYMORPHISM LOCATED IN CMYA5 GENE AND DISEASE
Document Type and Number:
WIPO Patent Application WO/2007/013641
Kind Code:
A1
Abstract:
Disclosed are a method for detecting a genetic risk of a disease associated with an SNP located in a CMYA5 (cardiomyopathy associated 5) gene, a diagnostic agent and a diagnosis kit. More particularly, disclosed is a method for detecting a genetic component involved in a heart disease, a muscle disease, a renal disease, a hormone deficiency or the variation in creatinine level in the blood, in which it is detected, in a biological tissue, whether or not a CMYA5 gene in the genome has a nucleotide sequence that may cause the mutation in amino acid sequence of an expression product of the gene or the like.
Inventors:
NAKAGAMI HIRONORI (JP)
OGIHARA TOSHIO (JP)
KANEDA YASUFUMI (JP)
KATSUYA TOMOHIRO (JP)
AKASAKA HIROSHI (JP)
MORISHITA RYUICHI (JP)
MAEDA AKITO (JP)
KANAMORI TOSHIHIDE (JP)
OGIHARA TOSHIO (JP)
KANEDA YASUFUMI (JP)
KATSUYA TOMOHIRO (JP)
AKASAKA HIROSHI (JP)
MORISHITA RYUICHI (JP)
MAEDA AKITO (JP)
KANAMORI TOSHIHIDE (JP)
Application Number:
PCT/JP2006/315085
Publication Date:
February 01, 2007
Filing Date:
July 24, 2006
Export Citation:
Assignee:
GENOMIDEA INC (JP)
UNIV OSAKA (JP)
NAKAGAMI HIRONORI (JP)
OGIHARA TOSHIO (JP)
KANEDA YASUFUMI (JP)
KATSUYA TOMOHIRO (JP)
AKASAKA HIROSHI (JP)
MORISHITA RYUICHI (JP)
MAEDA AKITO (JP)
KANAMORI TOSHIHIDE (JP)
UNIV OSAKA (JP)
NAKAGAMI HIRONORI (JP)
OGIHARA TOSHIO (JP)
KANEDA YASUFUMI (JP)
KATSUYA TOMOHIRO (JP)
AKASAKA HIROSHI (JP)
MORISHITA RYUICHI (JP)
MAEDA AKITO (JP)
KANAMORI TOSHIHIDE (JP)
International Classes:
C12N15/09; C12Q1/68
Other References:
DATABASE GENBANK [online] "Homo sapiens cardiomyopathy associated 5 (CMYA5) mRNA)", XP003006682, Database accession no. (GI:62241002)
BENSOM M.A. ET AL.: "Myospryn is a novel binding partner for dysbindin in muscle", J. BIOL. CHEM., vol. 279, no. 11, 2004, pages 10450 - 10458, XP003006683
DATABASE ENSEMBL [online] XP003006684, Database accession no. (ENSP00000238522)
BENSOM M.A. ET AL.: "Myospryn is a novel binding partner for dysbindin in muscle", J. BIOL. CHEM., vol. 279, no. 11, 2004, pages 10450 - 10458, XP003006683
DATABASE ENSEMBL [online] XP003006684, Database accession no. (ENSP00000238522)
Attorney, Agent or Firm:
FURUYA, Satoshi et al. (2-17-8 Nihonbashi-Hamacho, Chuo-k, Tokyo 07, JP)
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