Title:
DETERMINATION METHOD OF AUTOIMMUNE DISEASE AND/OR INFLAMMATORY DISEASE, AND PREVENTIVE AND/OR THERAPEUTIC AGENT OF INFLAMMATORY DISEASE AND/OR AUTOIMMUNE DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/213699
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel method which, in the described circumstances, can determine likelihood of morbidity, severity, risk of onset and/or aggravation, treatment effects, etc., of inflammatory disease including Stevens-Johnson syndrome (SJS), which is an intractable ocular surface disease, or other autoimmune diseases. A further purpose of the present invention is to provide a novel therapeutic method for inflammatory disease including Stevens-Johnson syndrome (SJS), which is an intractable ocular surface disease, or other autoimmune diseases. The present invention is a method for determining autoimmune disease and/or inflammatory disease in a subject which targets at least one type of microRNA selected from the group consisting of miR-455-3p, miR-31-5p, miR-125a-5p, miR-72-5p, miR-628-3p, miR-548ac, miR-193b-5p, miR-204-3p and miR-3535 in a biological sample. Further, the present invention includes a preventive and/or a therapeutic agent of autoimmune disease and/or inflammatory disease which has a miR-455-3p inhibitor as the effective component.
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Inventors:
UETA MAYUMI (JP)
SOTOZONO CHIE (JP)
KINOSHITA SHIGERU (JP)
SOTOZONO CHIE (JP)
KINOSHITA SHIGERU (JP)
Application Number:
PCT/JP2020/016791
Publication Date:
October 22, 2020
Filing Date:
April 16, 2020
Export Citation:
Assignee:
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
ROHTO PHARMA (JP)
ROHTO PHARMA (JP)
International Classes:
A61P29/00; A61K31/7088; A61P37/00; C12N15/113; C12Q1/6876
Foreign References:
| US20170159123A1 | 2017-06-08 | |||
| JP2019506183A | 2019-03-07 |
Other References:
UETA, MAYUMI ET AL: "Comprehensive miRNA analysis of the conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage", NIPPON GANKA GAKKAIZASSHI, vol. 123, 2020, XP055751165
MORI, RYOICHI: "Elucidation of trauma and inflammatory diseases and establishment of new treatment methods", RESEARCH REPORTS OF THE UEHARA MEMORIAL FOUNDATION, vol. 25, 2011, pages 1 - 5
JINNIN, MASATOSHI: "microRNA in autoimmune disorders", JPN. J. CLIN. IMMUNOL., vol. 34, 2011, pages 439 - 446, XP055751182
UMEMURA, TSUKURU: "MicroRNAs as the new disease biomarker", JOURNAL OF ANALYTICAL BIOSCIENCE, vol. 39, 2016, pages 311 - 320
MORI, RYOICHI: "Elucidation of trauma and inflammatory diseases and establishment of new treatment methods", RESEARCH REPORTS OF THE UEHARA MEMORIAL FOUNDATION, vol. 25, 2011, pages 1 - 5
JINNIN, MASATOSHI: "microRNA in autoimmune disorders", JPN. J. CLIN. IMMUNOL., vol. 34, 2011, pages 439 - 446, XP055751182
UMEMURA, TSUKURU: "MicroRNAs as the new disease biomarker", JOURNAL OF ANALYTICAL BIOSCIENCE, vol. 39, 2016, pages 311 - 320
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES (JP)
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