Title:
DEUTERATED AMINOPYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/099242
Kind Code:
A1
Abstract:
Provided are a deuterated aminopyridine derivative as represented by formula I, an optical isomer or mixture thereof, a polymorph thereof, a salt thereof, or a hydrate or solvate thereof; further provided is a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the deuterated aminopyridine derivative, the optical isomer or mixture thereof, the polymorph thereof, the salt thereof, or the hydrate or solvate thereof. The compound represented by general formula I serves as a BTK inhibitor, is a prophylactic and/or therapeutic agent for BTK-related diseases, has low hepatic toxicity, and has a good therapeutic effect on allergic diseases, autoimmune diseases, inflammatory diseases, thromboembolic diseases, or cancers.
Inventors:
BAO RONGXIAO (CN)
Application Number:
PCT/CN2023/129826
Publication Date:
May 16, 2024
Filing Date:
November 04, 2023
Export Citation:
Assignee:
TIANJIN ZHENGCHENG MEDICAL TECH CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/4545; A61P9/00; A61P19/02; A61P35/00; A61P37/00
Domestic Patent References:
| WO2022218430A1 | 2022-10-20 | |||
| WO2022171140A1 | 2022-08-18 |
Foreign References:
| CN105753863A | 2016-07-13 | |||
| CN106459049A | 2017-02-22 | |||
| CN110563733A | 2019-12-13 |
Attorney, Agent or Firm:
BEIJING JUNYOU INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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