DEXANABINOL AND DEXANABINOL ANALOGS REGULATE INFLAMMATION RELATED GENES

Title:

DEXANABINOL AND DEXANABINOL ANALOGS REGULATE INFLAMMATION RELATED GENES

Document Type and Number:

WIPO Patent Application WO2003077832

Kind Code:

A3

Abstract:

The present invention relates to pharmaceutical compositions comprising as an active ingredient non-psychotropic cannabinoid derivatives that modulate the expression of genes involved in inflammatory and immune processes. Regulating the transcription of pro and anti-inflammatory mediators has useful therapeutic application for prevention and treatment of acute and chronic inflammation, autoimmune diseases and related disorders, pain, infections, liver diseases, cardiovascular disorders, gastrointestinal disorders, disorders of the central and peripheral nervous system including neurodegenerative diseases, respiratory diseases, renal diseases, post-operative complications, tissue rejection and certain types of cancer.

Inventors:

GARZON AARON (IL)
AVRAHAM AYELET (IL)
FINK GEORGE (IL)

Application Number:

PCT/IL2003/000223

Publication Date:

December 31, 2003

Filing Date:

March 16, 2003

Export Citation:

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Assignee:

PHARMOS CORP (US)
GARZON AARON (IL)
AVRAHAM AYELET (IL)
FINK GEORGE (IL)

International Classes:

A61K31/352; C07D311/78; A61K31/353; A61K31/4155; A61K31/4178; A61K31/453; A61K31/4545; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/06; A61P31/12; A61P33/00; A61P35/00; A61P37/06; A61P37/08; (IPC1-7): A61K31/35

Foreign References:

US6331560B1

2001-12-18

Other References: