Title:
DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE AND IRRITABLE BOWEL SYNDROME
Document Type and Number:
WIPO Patent Application WO/2012/172347
Kind Code:
A9
Abstract:
A method of diagnosing, monitoring progression of, or monitoring treatment of inflammatory bowel disease comprises determining the levels of CD14+HLA-DRhi monocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9 in a sample obtained from a subject, wherein high levels of CD14+HLA-DRhi monocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9, or increased levels of CD14+HLA-DRhi monocytes or monocytes expressing CCR7 or CCR9 or both CCR7 and CCR9 compared to control, indicate the presence or progression of inflammatory bowel disease. Similar methods for diagnosing irritable bowel syndrome are also described. Various companion therapeutic methods and useful binding reagents are also described.
Inventors:
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
COTTON GRAHAM (GB)
Application Number:
PCT/GB2012/051357
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
ITH IMMUNE THERAPY HOLDINGS AB (SE)
COTTON GRAHAM (GB)
ITH IMMUNE THERAPY HOLDINGS AB (SE)
International Classes:
G01N33/68; A61M1/36; B01J20/32; C07K14/52; C07K17/00; G01N33/50
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn Road, London Greater London WC1X 8BT, GB)
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