Title:
TREATING RESPIRATORY CONDITIONS
Document Type and Number:
WIPO Patent Application WO/2012/172346
Kind Code:
A3
Abstract:
A method for treating a respiratory conditions comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR1, CCR3, CCR5, CXCR1, CXCR2 and/or CCR7 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR2, CCR1, CCR3, CCR5, CXCR1, CXCR2 and/or CCR7 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051356
Publication Date:
March 14, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/68
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 | |||
| WO2010021697A2 | 2010-02-25 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| US20030017979A1 | 2003-01-23 |
Other References:
M. N. SARAFI ET AL: "Murine Monocyte Chemoattractant Protein (MCP)-5: A Novel CC Chemokine That Is a Structural and Functional Homologue of Human MCP-1", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 185, no. 1, 1 January 1997 (1997-01-01), pages 99 - 110, XP055035882, ISSN: 0022-1007, DOI: 10.1084/jem.185.1.99
W. I. DE BOER: "Cytokines and Therapy in COPD* : A Promising Combination?", CHEST, vol. 121, no. 90050, 1 May 2002 (2002-05-01), pages 209S - 218, XP055016980, ISSN: 0012-3692, DOI: 10.1378/chest.121.5_suppl.209S
M. PETREK ET AL: "CC and C chemokine expression in pulmonary sarcoidosis", EUROPEAN RESPIRATORY JOURNAL, vol. 20, no. 5, 1 November 2002 (2002-11-01), pages 1206 - 1212, XP055038422, ISSN: 0903-1936, DOI: 10.1183/09031936.02.00289902
W. I. DE BOER: "Cytokines and Therapy in COPD* : A Promising Combination?", CHEST, vol. 121, no. 90050, 1 May 2002 (2002-05-01), pages 209S - 218, XP055016980, ISSN: 0012-3692, DOI: 10.1378/chest.121.5_suppl.209S
M. PETREK ET AL: "CC and C chemokine expression in pulmonary sarcoidosis", EUROPEAN RESPIRATORY JOURNAL, vol. 20, no. 5, 1 November 2002 (2002-11-01), pages 1206 - 1212, XP055038422, ISSN: 0903-1936, DOI: 10.1183/09031936.02.00289902
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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