Title:
DIHYDROXYHEXENOIC ACID ESTER AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2010/143700
Kind Code:
A1
Abstract:
Disclosed is a method whereby oseltamivir can be safely and stably produced in a large amount, via a dihydroxyhexenoic acid ester represented by formula (1), by using tartaric acid, mannitol or arabinose as a starting material. In formula (1), R1, R2 and R6 are the same or different and each represents an alkyl group, an aryl group, a substituted aryl group, an aralkyl group, a substituted aralkyl group or an aromatic heterocyclic group, provided that R1 and R2 do not represent methyl at the same time.
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Inventors:
ISHIKAWA TERUHIKO (JP)
SAITO SEIKI (JP)
KUDOH TAKAYUKI (JP)
SUDO KOUTARO (JP)
NISHIUCHI HIRONORI (JP)
OKADA MAKOTO (JP)
TANIGUCHI MASATOSHI (JP)
SAITO SEIKI (JP)
KUDOH TAKAYUKI (JP)
SUDO KOUTARO (JP)
NISHIUCHI HIRONORI (JP)
OKADA MAKOTO (JP)
TANIGUCHI MASATOSHI (JP)
Application Number:
PCT/JP2010/059889
Publication Date:
December 16, 2010
Filing Date:
June 04, 2010
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
ISHIKAWA TERUHIKO (JP)
SAITO SEIKI (JP)
KUDOH TAKAYUKI (JP)
SUDO KOUTARO (JP)
NISHIUCHI HIRONORI (JP)
OKADA MAKOTO (JP)
TANIGUCHI MASATOSHI (JP)
ISHIKAWA TERUHIKO (JP)
SAITO SEIKI (JP)
KUDOH TAKAYUKI (JP)
SUDO KOUTARO (JP)
NISHIUCHI HIRONORI (JP)
OKADA MAKOTO (JP)
TANIGUCHI MASATOSHI (JP)
International Classes:
C07C205/50; C07D317/30; C07D317/32; C07D493/04
Foreign References:
| JPH08104687A | 1996-04-23 | |||
| JPH09241206A | 1997-09-16 |
Other References:
KILLIAN D.B. ET AL: "The Synthesis of some dioxole derivatives from alkylacetylenes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 58, 1936, pages 1658 - 1659
KRISHNA, P.R. ET AL.: "The Baylis-Hillman reaction: A strategic tool for the synthesis of higher-carbon sugars", TETRAHEDRON LETTERS, vol. 48, no. 37, 2007, pages 6466 - 6470, XP022201098, DOI: doi:10.1016/j.tetlet.2007.07.067
HOLLINGSWORTH, R.I.: "Taming carbohydrate complexity: a facile, high-yield route to chiral 2,3-dihydroxybutanoic acids and 4-hydroxytetrahydrofuran-2-ones with very high optical purity from pentose sugars", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 20, 1999, pages 7633 - 7634, XP002316782, DOI: doi:10.1021/jo991069w
KRISHNA, P.R. ET AL.: "The Baylis-Hillman reaction: A strategic tool for the synthesis of higher-carbon sugars", TETRAHEDRON LETTERS, vol. 48, no. 37, 2007, pages 6466 - 6470, XP022201098, DOI: doi:10.1016/j.tetlet.2007.07.067
HOLLINGSWORTH, R.I.: "Taming carbohydrate complexity: a facile, high-yield route to chiral 2,3-dihydroxybutanoic acids and 4-hydroxytetrahydrofuran-2-ones with very high optical purity from pentose sugars", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 20, 1999, pages 7633 - 7634, XP002316782, DOI: doi:10.1021/jo991069w
Attorney, Agent or Firm:
TAMURA, Iwao (JP)
Tamura 巌 (JP)
Tamura 巌 (JP)
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