Title:
DISRUPTION OF THE REG PATHWAY
Document Type and Number:
WIPO Patent Application WO2004092352
Kind Code:
A3
Abstract:
Disruption of the Reg signalling pathway permits spontaneous and therapeutic induction of pro-apoptotic signals to be more effective. Disruption can be accomplished by means of antibodies, antisense, RNA interference, small molecule inhibitors, etc. These can be used in conjunction with conventional anti-neoplastic therapies. Inhibitors can be identified by assays that monitor the disruption of the binding of Reg ligands and the Reg ligand receptor.
Inventors:
DIECKGRAEFE BRIAN K (US)
KORZENIK JOSHUA R (US)
KORZENIK JOSHUA R (US)
Application Number:
PCT/US2004/009286
Publication Date:
February 02, 2006
Filing Date:
April 14, 2004
Export Citation:
Assignee:
UNIV WASHINGTON (US)
DIECKGRAEFE BRIAN K (US)
KORZENIK JOSHUA R (US)
DIECKGRAEFE BRIAN K (US)
KORZENIK JOSHUA R (US)
International Classes:
A61K31/365; A61K31/415; A61K48/00; C12N; (IPC1-7): A61K48/00; A61K39/395
Domestic Patent References:
| WO1998000561A1 | 1998-01-08 |
Foreign References:
| US5837841A | 1998-11-17 | |||
| US20030203361A1 | 2003-10-30 |
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