SURFACE RECEPTOR COMPLEXES AS BIOMARKERS

Title:

SURFACE RECEPTOR COMPLEXES AS BIOMARKERS

Document Type and Number:

WIPO Patent Application WO2004092353

Kind Code:

A3

Abstract:

The invention is directed to a new class of biomarker in patient samples comprising dimers of cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers. After binding, molecular tags are release and separated from the assay mixture for analysis.

Inventors:

CHAN-HUI PO-YING (US)
SALIMI-MOOSAVI HOSSEIN (US)
SHI YINING (US)
SINGH SHARAT (US)
DUA RAJIV (US)
MUKHERJEE ALI (US)
PIDAPARTHI SAILAJA (US)

Application Number:

PCT/US2004/009717

Publication Date:

March 03, 2005

Filing Date:

March 30, 2004

Export Citation:

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Assignee:

ACLARA BIOSCIENCES INC (US)
CHAN-HUI PO-YING (US)
SALIMI-MOOSAVI HOSSEIN (US)
SHI YINING (US)
SINGH SHARAT (US)
DUA RAJIV (US)
MUKHERJEE ALI (US)
PIDAPARTHI SAILAJA (US)

International Classes:

C07K16/28; C12Q3/00; G01N33/542; G01N33/543; G01N33/574; A61B; C12N; (IPC1-7): G01N33/543

Foreign References:

US20020127654A1	2002-09-12
US20020164641A1	2002-11-07

Other References: