Title:
DNA DOSAGE FORMS
Document Type and Number:
WIPO Patent Application WO2003061636
Kind Code:
A3
Abstract:
The present invention relates to efficient devices for administration of DNA based pharmaceutical agents into mammalian skin. In a particularly preferred aspect of the present invention there is provided devices for administration of DNA vaccines into the skin of the mammal, and preferably into human skin. The present invention provides a microneedle DNA pharmaceutical agent delivery device having at least one skin-piercing element which comprises a support member coated with a solid reservoir medium containing, in solid solution or suspension within it, the DNA pharmaceutical agent, and a stabilising agent that inhibits the degradative effects of free radicals. Preferably the solid pharmaceutical reservoir medium coated onto such devices is a polyol, preferably being a polyol in an amorphous state (such as a glass).
Inventors:
CATCHPOLE IAN RICHARD (GB)
Application Number:
PCT/GB2003/000282
Publication Date:
November 27, 2003
Filing Date:
January 23, 2003
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
CATCHPOLE IAN RICHARD (GB)
CATCHPOLE IAN RICHARD (GB)
International Classes:
A61K9/70; A61K9/16; A61K31/7088; A61K39/00; A61K47/04; A61K47/10; A61K47/12; A61K47/18; A61K47/20; A61K47/22; A61K47/24; A61K47/26; A61K47/42; A61M37/00; A61K9/14; (IPC1-7): A61K9/70; C12N15/89; A61M37/00; A61B17/20
Domestic Patent References:
| WO1996013277A1 | 1996-05-09 | |||
| WO1997040839A1 | 1997-11-06 |
Foreign References:
| EP1138337A2 | 2001-10-04 |
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