Title:
USE OF PHOSPHODIESTERASE ANTAGONISTS TO TREAT INSULIN RESISTANCE
Document Type and Number:
WIPO Patent Application WO2003061638
Kind Code:
A3
Abstract:
There is provided the use of a phosphodiesterase antagonist to reduce insulin resistance, and to amplify the effect of nitric oxide on skeletal muscle insulin-mediated glucose uptake in a mammal. In some instances, the antagonist is targeted to the liver. In some instances, the insulin resistance is hepatic insulin sensitizing substance ("HISS") dependant insulin resistance.
Inventors:
LAUTT WAYNE W (CA)
MACEDO PAULA (PT)
MACEDO PAULA (PT)
Application Number:
PCT/CA2003/000077
Publication Date:
October 02, 2003
Filing Date:
January 27, 2003
Export Citation:
Assignee:
LAUTT WAYNE W (CA)
MACEDO PAULA (PT)
DIAMEDICA INC (CA)
MACEDO PAULA (PT)
DIAMEDICA INC (CA)
International Classes:
A61K31/00; A61K31/40; A61K31/4166; A61K31/4375; A61K31/444; A61K31/445; A61K31/4709; A61K31/505; A61K31/519; A61K31/52; A61K31/522; A61K31/53; A61K45/06; A61P3/10; (IPC1-7): A61K31/00; A61K31/40; A61K31/4166; A61K31/444; A61K31/4375; A61K31/4709; A61K31/519; A61K31/52; A61K31/522; A61P3/10
Domestic Patent References:
| WO2003028730A2 | 2003-04-10 | |||
| WO2002024698A1 | 2002-03-28 | |||
| WO2002013798A2 | 2002-02-21 |
Foreign References:
| EP1142879A1 | 2001-10-10 | |||
| EP1020452A1 | 2000-07-19 |
Other References:
Y. NAKAYA ET AL: "Cilostazol, a phosphodiesterase inhibitor, improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty Rat, a model of spontaneous NIDDM", DIABETES, OBESITY AND METABOLISM, vol. 1, no. 1, January 1999 (1999-01-01), pages 37 - 41, XP002248686
LAUTT W W: "THE HISS STORY OVERVIEW: A NOVEL HEPATIC NEUROHUMORAL REGULATION OF PERIPHERAL INSULIN SENSITIVITY IN HEALTH AND DIABETES", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, OTTAWA, ONT, CA, vol. 77, no. 8, August 1999 (1999-08-01), pages 553 - 562, XP009011015
PETRIE J R ET AL: "ENDOTHELIAL NITRIC OXIDE PRODUCTION AND INSULIN SENSITIVITY. A PHYSIOLOGICAL LINK WITH IMPLICATIONS FOR PATHOGENESIS OF CARDIOVASCULAR DISEASE", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 93, no. 7, 1 April 1996 (1996-04-01), pages 1331 - 1333, XP002924506, ISSN: 0009-7322
ALISON J. EVANS ET AL: "Insulin resistance and beta-cell dysfunction as therapeutic targets in type 2 diabetes", DIABETES, OBESITY AND METABOLISM, vol. 3, 2001, pages 219 - 229, XP002248687
LAUTT W W: "THE HISS STORY OVERVIEW: A NOVEL HEPATIC NEUROHUMORAL REGULATION OF PERIPHERAL INSULIN SENSITIVITY IN HEALTH AND DIABETES", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, OTTAWA, ONT, CA, vol. 77, no. 8, August 1999 (1999-08-01), pages 553 - 562, XP009011015
PETRIE J R ET AL: "ENDOTHELIAL NITRIC OXIDE PRODUCTION AND INSULIN SENSITIVITY. A PHYSIOLOGICAL LINK WITH IMPLICATIONS FOR PATHOGENESIS OF CARDIOVASCULAR DISEASE", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 93, no. 7, 1 April 1996 (1996-04-01), pages 1331 - 1333, XP002924506, ISSN: 0009-7322
ALISON J. EVANS ET AL: "Insulin resistance and beta-cell dysfunction as therapeutic targets in type 2 diabetes", DIABETES, OBESITY AND METABOLISM, vol. 3, 2001, pages 219 - 229, XP002248687
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