Title:
DNA EXPRESSION VECTORS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2001092470
Kind Code:
A3
Abstract:
The present invention provides novel pGA constructs which are useful as vectors for the delivery of DNA vaccine inserts. The vaccine inserts can include the DNA transcripts of various virus, bacteria, parasite and/or fungi. Also described are methods of raising multi-epitope CD8 T-cell responses by administering therapeutically effective amounts of the novel pGA constructs comprising pathogen vaccine inserts followed by booster immunizations with a live vectored vaccine comprising the same vaccine inserts.
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Inventors:
ROBINSON HARRIET L
SMITH JAMES M
ROSS TED M
BRIGHT RICK ARTHUR
HUA JIAN
ELLENBERGER DENNIS
SMITH JAMES M
ROSS TED M
BRIGHT RICK ARTHUR
HUA JIAN
ELLENBERGER DENNIS
Application Number:
PCT/US2001/006795
Publication Date:
March 25, 2004
Filing Date:
March 02, 2001
Export Citation:
Assignee:
UNIV EMORY (US)
International Classes:
C12N15/09; A61K35/76; A61K39/145; A61K39/165; A61K39/21; A61K48/00; C07K14/16; C07K14/47; C07K16/10; C12N15/63; C12N15/67; C12N15/70; C12N15/85; A61K39/00; (IPC1-7): A61K39/21; A61K39/275; A01N63/00; C07H21/04; C12N15/74; C12N15/86; C12N15/97
Other References:
KENT ET AL.: "Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant Fowlpox virus", JOURNAL OF VIROLOGY, vol. 72, no. 12, December 1998 (1998-12-01), pages 10180 - 10188, XP002179215
BOHM ET AL.: "Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses", VACCINE, vol. 16, no. 9/10, 1998, pages 945 - 954, XP002973435
ROBINSON ET AL.: "Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations", NATURE MEDICINE, vol. 5, no. 5, May 1999 (1999-05-01), pages 526 - 534, XP001135061
BOHM ET AL.: "Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses", VACCINE, vol. 16, no. 9/10, 1998, pages 945 - 954, XP002973435
ROBINSON ET AL.: "Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations", NATURE MEDICINE, vol. 5, no. 5, May 1999 (1999-05-01), pages 526 - 534, XP001135061
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