Title:
DNA POLYMERASE θ INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169547
Kind Code:
A1
Abstract:
A nitrogen-containing heterocyclic compound represented by formula (I-c), or a stereoisomer, a deuterated compound or a pharmaceutically acceptable salt, and a pharmaceutical composition thereof. Also provided is a use of the compound in the preparation of a drug for treating a DNA polymerase θ-mediated disease. Each group in formula (I-c) is as defined in the description.
Inventors:
LI YAO (CN)
ZHANG GUOBIAO (CN)
WANG YAOLING (CN)
LIU MAN (CN)
ZHENG DENGYU (CN)
WANG ZHENG (CN)
WANG SHUN (CN)
ZHONG QIJIE (CN)
TANG PINGMING (CN)
YU YAN (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
ZHANG GUOBIAO (CN)
WANG YAOLING (CN)
LIU MAN (CN)
ZHENG DENGYU (CN)
WANG ZHENG (CN)
WANG SHUN (CN)
ZHONG QIJIE (CN)
TANG PINGMING (CN)
YU YAN (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2023/080706
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4439; C07D401/04; A61P35/00; C07D413/14; C07D471/04
Domestic Patent References:
| WO2022167817A1 | 2022-08-11 | |||
| WO2021028643A1 | 2021-02-18 | |||
| WO2021028670A1 | 2021-02-18 |
Foreign References:
| CN114127062A | 2022-03-01 |
Other References:
STOCKLEY MARTIN L., FERDINAND AMANDA, BENEDETTI GIOVANNI, BLENCOWE PETER, BOYD SUSAN M., CALDER MAT, CHARLES MARK D., EDWARDES LUC: "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 65, no. 20, 27 October 2022 (2022-10-27), US , pages 13879 - 13891, XP093089562, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.2c01142
Attorney, Agent or Firm:
WU , FENG & ZHANG (CN)
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