Title:
LPA INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169548
Kind Code:
A1
Abstract:
Provided is an RNA inhibitor or a pharmaceutically acceptable salt thereof for inhibiting LPA gene expression, the RNA inhibitor comprising a complementary region of an antisense strand, and the complementary region comprising at least 15 continuous nucleotides; the antisense strand comprises following nucleotide sequences: any one of the sequences SEQ ID NO. 414-418, and a sequence having at least 15 continuous nucleotides the same as those in SEQ ID NO. 414-418, or a sequence having no more than three nucleotides different from those in the above sequence. The RNA inhibitor directly degrades LPAmRNA and continuously and efficiently inhibits LPA gene expression, and therefore can be used for treating or preventing LPA gene-mediated related cardiovascular and cerebrovascular diseases.
Inventors:
CUI KUNYUAN (CN)
LU XUEQIN (CN)
MU ZHUO (CN)
LU XUEQIN (CN)
MU ZHUO (CN)
Application Number:
PCT/CN2023/080708
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
KYLONOVA XIAMEN BIOPHARMA CO LTD (CN)
International Classes:
C12N15/113; A61K31/713; A61P1/16; A61P3/00; A61P3/06; A61P7/02; A61P9/10; A61P29/00
Domestic Patent References:
| WO2022032288A1 | 2022-02-10 | |||
| WO2022121959A1 | 2022-06-16 | |||
| WO2023041079A1 | 2023-03-23 |
Foreign References:
| CN111465694A | 2020-07-28 | |||
| US20030119766A1 | 2003-06-26 | |||
| EP3483270A1 | 2019-05-15 | |||
| US20040138164A1 | 2004-07-15 | |||
| CN114703184A | 2022-07-05 | |||
| CN115851723A | 2023-03-28 | |||
| CN108359668A | 2018-08-03 | |||
| CN113171371A | 2021-07-27 |
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