Title:
DOTA-BIOTIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1999030745
Kind Code:
A3
Abstract:
A radionuclide-chelator conjugate composition for detecting and/or treating lesions in a patient in a pre-targeting protocol which comprises pre-targeting the target cell, tissue, or pathogen with a substrate, using a targeting protein that specifically binds a marker substance on the target cell, tissue, or pathogen and to which the substrate is directly or indirectly bound; parenterally injecting the detection or therapeutic composition of the invention which comprises a chelate conjugate of biotin, a chelator, and a chelatable detection or therapeutic agent, and allowing the compsition to accrete at the targeted cell, tissue, or pathogen; wherein the chelate conjugate is purified by chromatography after chelate formation, or further comprises a blood transit-modifying linker or addend that is covalently bound within the chelate conjugate, or both; and using the detection or therapeutic agent to detect or treat the targeted cell, tissue, or pathogen.
Inventors:
GRIFFITHS GARY L (US)
HANSEN HANS (US)
GOVINDAN SERENGULAM V (US)
HANSEN HANS (US)
GOVINDAN SERENGULAM V (US)
Application Number:
PCT/US1998/026579
Publication Date:
January 13, 2000
Filing Date:
December 15, 1998
Export Citation:
Assignee:
IMMUNOMEDICS INC (US)
GRIFFITHS GARY L (US)
HANSEN HANS (US)
GOVINDAN SERENGULAM V (US)
GRIFFITHS GARY L (US)
HANSEN HANS (US)
GOVINDAN SERENGULAM V (US)
International Classes:
A61K41/00; A61K47/48; A61K49/08; A61K51/04; A61K51/10; G01N33/531; G01N33/534; G01N33/574; G01N33/68; (IPC1-7): A61K51/00; A61K51/04; A61K47/48
Domestic Patent References:
| WO1998004293A1 | 1998-02-05 | |||
| WO1995028967A1 | 1995-11-02 | |||
| WO1995014493A1 | 1995-06-01 |
Foreign References:
| US5624896A | 1997-04-29 |
Other References:
KARACAY H ET AL: "Development of a streptavidin-anti-carcinoembryonic antigen antibody, radiolabeled biotin pretargeting method for radioimmunotherapy of colorectal cancer. Reagent development", BIOCONJUGATE CHEMISTRY, vol. 8, July 1997 (1997-07-01), pages 585 - 594, XP002075839
GOODWIN D.A.: "Tumor Pretargeting: Almost the Bottom Line", THE JOURNAL OF NUCLEAR MEDICINE, vol. 36, no. 5, 1995, pages 876 - 879, XP002100555
PAGANELLI G ET AL: "MONOCLONAL ANTIBODY PRETARGETING TECHNIQUES FOR TUMOUR LOCALIZATIONTHE AVIDIN-BIOTIN SYSTEM", NUCLEAR MEDICINE COMMUNICATIONS, vol. 12, no. 3, 1 March 1991 (1991-03-01), pages 211 - 234, XP000373577
GOODWIN D.A.: "Tumor Pretargeting: Almost the Bottom Line", THE JOURNAL OF NUCLEAR MEDICINE, vol. 36, no. 5, 1995, pages 876 - 879, XP002100555
PAGANELLI G ET AL: "MONOCLONAL ANTIBODY PRETARGETING TECHNIQUES FOR TUMOUR LOCALIZATIONTHE AVIDIN-BIOTIN SYSTEM", NUCLEAR MEDICINE COMMUNICATIONS, vol. 12, no. 3, 1 March 1991 (1991-03-01), pages 211 - 234, XP000373577
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