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Title:
DOUBLE-STRANDED RNA MOLECULE TARGETING CKIP-1 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/047914
Kind Code:
A1
Abstract:
Provided are a double-stranded RNA molecule targeting CKIP-1 and a use thereof in treating an inflammatory disease including rheumatoid arthritis.

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Inventors:
ZHAO YANPING (CN)
WANG HONGJUN (CN)
JIANG YUANYUAN (CN)
ZHONG WEITING (CN)
PANG JIANMEI (CN)
LI GONG (CN)
LI XIANG (CN)
HE YIXIN (CN)
ZHOU LIYING (CN)
LIU YANAN (CN)
Application Number:
PCT/CN2018/104552
Publication Date:
March 14, 2019
Filing Date:
September 07, 2018
Export Citation:
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Assignee:
BEIJING TIDE PHARMACEUTICAL CO LTD (CN)
International Classes:
C12N15/11; A61K48/00; A61P19/02; A61P19/08; A61P19/10; C12N15/63
Domestic Patent References:
WO2015027895A12015-03-05
WO1999032619A11999-07-01
WO1999053050A11999-10-21
WO1999061631A11999-12-02
WO2000044895A12000-08-03
Foreign References:
EP2213738A22010-08-04
DE10100586A2001-01-09
Other References:
CHEN JUNFENG ET AL.: "MicroRNA-20a Promotes Osteogenic Differentiation of C3H/10T1/2 Cells trough Regulating CKIP-1 Expression ", JOURNAL OF EXPERIMENTAL HEMATOLOGY, vol. 25, no. 1, 20 February 2017 (2017-02-20), pages 214 - 220, XP009519161, ISSN: 1009-2137, DOI: 10.7534/j.issn.1009-2137.2017.01.038
GUO B.: "Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation", BONE, vol. 59, no. 2014, 15 November 2013 (2013-11-15) - February 2014 (2014-02-01), pages 76 - 88, XP055580907, ISSN: 8756-3282, DOI: 10.1016/j.bone.2013.11.007
"Molecular Cloning: A Laboratory Manual", 1982, COLD SPRING HARBOR LABORATORY
YANG, D. ET AL., CURR. BIOL., vol. 10, 2000, pages 1191 - 1200
"Molecular Cloning A Laboratory Manual", 2005, SCIENCE PRESS
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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