Title:
IMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2019/047915
Kind Code:
A1
Abstract:
Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3Kδ related disorders or diseases by using the compound disclosed herein.
Inventors:
LI JING (CN)
ZHAO HAIBO (CN)
WANG ZHIWEI (CN)
ZHAO HAIBO (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2018/104559
Publication Date:
March 14, 2019
Filing Date:
September 07, 2018
Export Citation:
Assignee:
BEIGENE LTD (KY)
LI JING (CN)
LI JING (CN)
International Classes:
C07D487/04; A61K31/4985; A61P35/00; A61P37/00
Domestic Patent References:
| WO2018103688A1 | 2018-06-14 | |||
| WO2015058084A1 | 2015-04-23 | |||
| WO2010119264A1 | 2010-10-21 | |||
| WO2014071109A1 | 2014-05-08 | |||
| WO2012107465A1 | 2012-08-16 | |||
| WO2013104610A1 | 2013-07-18 | |||
| WO2016024230A1 | 2016-02-18 |
Other References:
VANHAESEBROECK, B.L. STEPHENSP. HAWKINS: "PI3K signalling: the path to discovery and understanding", NAT REV MOL CELL BIOL, vol. 13, no. 3, 2012, pages 195 - 203
WHITMAN, M. ET AL.: "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate", NATURE, vol. 332, no. 6165, 1988, pages 644 - 6, XP002037805, DOI: 10.1038/332644a0
AUGER, K.R. ET AL.: "PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells", CELL, vol. 57, no. 1, 1989, pages 167 - 75, XP024244349, DOI: 10.1016/0092-8674(89)90182-7
MARTIN, T.F.: "Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking", ANNU REV CELL DEV BIOL, vol. 14, 1998, pages 231 - 64, XP002927310, DOI: 10.1146/annurev.cellbio.14.1.231
See also references of EP 3679042A4
WHITMAN, M. ET AL.: "Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate", NATURE, vol. 332, no. 6165, 1988, pages 644 - 6, XP002037805, DOI: 10.1038/332644a0
AUGER, K.R. ET AL.: "PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells", CELL, vol. 57, no. 1, 1989, pages 167 - 75, XP024244349, DOI: 10.1016/0092-8674(89)90182-7
MARTIN, T.F.: "Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking", ANNU REV CELL DEV BIOL, vol. 14, 1998, pages 231 - 64, XP002927310, DOI: 10.1146/annurev.cellbio.14.1.231
See also references of EP 3679042A4
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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