Title:
DRUG COMPOSITION USED FOR TREATMENT OF ANGIOGENESIS-DEPENDENT DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/097634
Kind Code:
A1
Abstract:
A drug composition according to the present invention is characterized by having, as an active ingredient, at least one selected from the group consisting of FasL expression inhibitors, angiogenesis inhibitors, and STING agonists, and using in therapy that combines the use of a STING agonist with an FasL expression inhibitor or angiogenesis inhibitor for the treatment of angiogenesis-dependent diseases.
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Inventors:
NAKAMURA TAKASHI (JP)
HARASHIMA HIDEYOSHI (JP)
ENDO RIKITO (JP)
HARASHIMA HIDEYOSHI (JP)
ENDO RIKITO (JP)
Application Number:
PCT/JP2021/040374
Publication Date:
May 12, 2022
Filing Date:
November 02, 2021
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K45/06; A61K9/51; A61K31/7084; A61K31/7088; A61K39/395; A61K47/24; A61K47/42; A61K47/69; A61K48/00; A61P35/00; A61P43/00; C12N15/11
Foreign References:
| US6268350B1 | 2001-07-31 | |||
| JP2007536324A | 2007-12-13 |
Other References:
YANG HANNAH, LEE WON SUK, KONG SO JUNG, KIM CHANG GON, KIM JOO HOON, CHANG SEI KYUNG, KIM SEWHA, KIM GWANGIL, CHON HONG JAE, KIM C: "STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade", THE JOURNAL OF CLINICAL INVESTIGATION, B M J GROUP, GB, vol. 129, no. 10, 1 October 2019 (2019-10-01), GB , pages 4350 - 4364, XP055927642, ISSN: 0021-9738, DOI: 10.1172/JCI125413
SAKURAI YU, HATAKEYAMA HIROTO, SATO YUSUKE, HYODO MAMORU, AKITA HIDETAKA, OHGA NORITAKA, HIDA KYOKO, HARASHIMA HIDEYOSHI: "RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 173, 1 January 2014 (2014-01-01), AMSTERDAM, NL , pages 110 - 118, XP055927641, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2013.10.003
SAKURAI YU, HATAKEYAMA HIROTO, SATO YUSUKE, HYODO MAMORU, AKITA HIDETAKA, OHGA NORITAKA, HIDA KYOKO, HARASHIMA HIDEYOSHI: "RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 173, 1 January 2014 (2014-01-01), AMSTERDAM, NL , pages 110 - 118, XP055927641, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2013.10.003
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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