DRUG DELIVERY PEPTIDES FOR CROSSING BLOOD-BRAIN BARRIER

Title:

DRUG DELIVERY PEPTIDES FOR CROSSING BLOOD-BRAIN BARRIER

Document Type and Number:

WIPO Patent Application WO2006061101

Kind Code:

A3

Abstract:

Disclosed is a peptide comprising the sequence: H₂N-Gly-Phe-D-Thr-Gly-Phe-Leu-Ser-CONH₂, wherein the serine residue may be functionalised with sugar residues; other aminoacids can replace the first two aminoacids of the N-terminal portion, the order of which can be reversed, and their number may be different from two.

Inventors:

FORNI FLAVIO (IT)
VANDELLI MARIA ANGELA (IT)
CONSTANTINO LUCA (IT)

Application Number:

PCT/EP2005/012554

Publication Date:

September 14, 2006

Filing Date:

November 24, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNI DEGLI STUDI DI MODENA E RE (IT)
FORNI FLAVIO (IT)
VANDELLI MARIA ANGELA (IT)
CONSTANTINO LUCA (IT)

International Classes:

C07K9/00; A61K47/48; C07K7/06

Domestic Patent References:

WO2002089776A1

2002-11-14

Other References:

ELMAGBARI NURA O ET AL: "Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides.", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. OCT 2004, vol. 311, no. 1, October 2004 (2004-10-01), pages 290 - 297, XP002386302, ISSN: 0022-3565
COSTANTINO LUCA ET AL: "Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier.", JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY. 2 NOV 2005, vol. 108, no. 1, 2 November 2005 (2005-11-02), pages 84 - 96, XP002386303, ISSN: 0168-3659

Download PDF:

View/Download PDF PDF Help

Previous Patent: PNEUMATIC SPRING SHOCK ABSORBER UNIT

Next Patent: METHOD FOR PRODUCING ORGANOSILANES