Title:
DRUG FOR ENHANCING FIBRINOLYTIC SYSTEM, AND USE THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/235532
Kind Code:
A1
Abstract:
A drug for enhancing the fibrinolytic system containing a compound represented by general formula (1) (in the formula, R1 represents a quinolyl group, R2 represents a halogen atom, and R3 represents a carboxy group or a biologically equivalent group thereof) or a pharmaceutically acceptable salt thereof as an active ingredient, wherein said drug for enhancing the fibrinolytic system is characterized by the daily dose of the active ingredient being 120-300 mg and by the drug being orally administered to a patient suffering from a disease in which an improvement in pathological condition is expected as a result of enhancement of the fibrinolytic system.
Inventors:
MIYATA TOSHIO (JP)
Application Number:
PCT/JP2021/019259
Publication Date:
November 25, 2021
Filing Date:
May 20, 2021
Export Citation:
Assignee:
RENASCIENCE INC (JP)
International Classes:
A61K31/47; A61P7/02; A61P11/00
Domestic Patent References:
| WO2010113022A1 | 2010-10-07 | |||
| WO2010113022A1 | 2010-10-07 |
Other References:
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RAWAL G ET AL., J TRANSL INT MED., vol. 6, 2018, pages 74 - 77
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PRABHAKARAN P ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL, vol. 285, no. 1, 2003, pages L20 - 8
BRUN-BUISSON C ET AL., INTENSIVE CARE MED, vol. 30, no. 1, 2004, pages 51 - 61
SAPRU A ET AL., INTENSIVE CARE MED, vol. 36, no. 1, 2010, pages 157 - 163
OZOLINA ET AL., A PROSPECTIVE PILOT STUDY FRONT MED (LAUSANNE, vol. 3, 28 November 2016 (2016-11-28), pages 64
EL SOLH AA ET AL., INTENSIVE CARE MED., vol. 32, no. 1, 2006, pages 110 - 115
WARE LB ET AL., CRIT CARE MED., vol. 35, no. 8, 2007, pages 1821 - 1828
ZHAO X ET AL., J BIOL CHEM., vol. 283, no. 6, 2008, pages 3272 - 3280
ZHE XU ET AL., LANCET RESPIR MED, vol. 8, 2020, pages 420 - 422
DOLHNIKOFF ET AL., J THROMB HAEMOST., vol. 18, 2020, pages 1548 - 55
WU Y ET AL., QJM, vol. 113, 2020, pages 539 - 45
ZHOU F ET AL., LANCET, vol. 395, 2020, pages 1054 - 62
BHANDARY ET AL., PLOS ONE, vol. 10, 2015, pages e0116504
HUANG WT ET AL., AM J RESPIR CELL MOL BIOL., vol. 46, no. 1, January 2012 (2012-01-01), pages 87
LIU RM ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL., vol. 310, 2016, pages L328
KOHARA ET AL., J. MED. CHEM., vol. 39, 1996, pages 5228 - 5235
ASHCROFT T ET AL., J CLIN PATHOL, vol. 41, 1988, pages 467
WU, Y. ET AL.: "Plasminogen improves lung lesions and hypoxemia in patients with COVID-19, QJM", INTERNATIONAL JOURNAL OF MEDICINE, vol. 113, no. 8, April 2020 (2020-04-01), pages 539 - 545, XP055835255, DOI: 10.1093/qjmed/hcaa121
YAMAOKA NAGAHISA, MURANO KENJI, KODAMA HIDEHIKO, MAEDA AKIHISA, DAN TAKASHI, NAKABAYASHI TETSUO, MIYATA TOSHIO, MEGURO KANJI: "Identification of novel plasminogen activator inhibitor-1 inhibitors with improved oral bioavailability: Structure optimization of N-acylanthranilic acid derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 28, no. 4, 1 February 2018 (2018-02-01), AMSTERDAM, NL , pages 809 - 813, XP055875056, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.11.016
KORTLEVER RM ET AL., NATURE CELL BIOLOGY, vol. 8, no. 8, 2006, pages 877 - 84
OZCAN S ET AL., AGING (ALBANY, NY, vol. 8, no. 7, 2016, pages 1316 - 29
LIEB W ET AL., CIRCULATION, vol. 119, no. 1, 6 January 2009 (2009-01-06), pages 37 - 43
BOE AE ET AL., CIRCULATION, vol. 128, no. 21, 2013, pages 2318 - 24
SONG C ET AL., J AM HEART ASSOC., vol. 6, no. 6, 26 May 2017 (2017-05-26)
EREN M ET AL., CIRCULATION, vol. 106, no. 4, 23 July 2002 (2002-07-23), pages 491 - 6
EITZMAN DT ET AL., J CLIN INVEST., vol. 97, no. 1, 1 January 1996 (1996-01-01), pages 232 - 7
RANA T ET AL., AM J RESPIR CELL MOL BIOL, vol. 62, 2020, pages 319 - 330
EREN M ET AL., PROC NATL ACAD SCI U S A., vol. 111, no. 19, 2014, pages 7090 - 5
FESTA A ET AL., DIABETES, vol. 51, no. 4, April 2002 (2002-04-01), pages 1131 - 7
CAMPBELL PT ET AL., CARDIA. LIVER INTERNATIONAL, 2020
GERENU G ET AL., BIOCHIM BIOPHYS ACTA MOL BASIS DIS., vol. 1863, no. 4, April 2017 (2017-04-01), pages 991 - 1001
JACOBSEN JS ET AL., PROC NATL ACAD SCI U S A., vol. 105, no. 25, 2008, pages 8754 - 8759
WARE LB ET AL., N ENGL J MED., vol. 342, 2000, pages 1334 - 49
RAWAL G ET AL., J TRANSL INT MED., vol. 6, 2018, pages 74 - 77
IDELL S ET AL., AM J PHYSIOL., vol. 261, 1991, pages L240 - 8
XUE M ET AL., J TRANSL MED, vol. 13, 2015, pages 172
PRABHAKARAN P ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL, vol. 285, no. 1, 2003, pages L20 - 8
BRUN-BUISSON C ET AL., INTENSIVE CARE MED, vol. 30, no. 1, 2004, pages 51 - 61
SAPRU A ET AL., INTENSIVE CARE MED, vol. 36, no. 1, 2010, pages 157 - 163
OZOLINA ET AL., A PROSPECTIVE PILOT STUDY FRONT MED (LAUSANNE, vol. 3, 28 November 2016 (2016-11-28), pages 64
EL SOLH AA ET AL., INTENSIVE CARE MED., vol. 32, no. 1, 2006, pages 110 - 115
WARE LB ET AL., CRIT CARE MED., vol. 35, no. 8, 2007, pages 1821 - 1828
ZHAO X ET AL., J BIOL CHEM., vol. 283, no. 6, 2008, pages 3272 - 3280
ZHE XU ET AL., LANCET RESPIR MED, vol. 8, 2020, pages 420 - 422
DOLHNIKOFF ET AL., J THROMB HAEMOST., vol. 18, 2020, pages 1548 - 55
WU Y ET AL., QJM, vol. 113, 2020, pages 539 - 45
ZHOU F ET AL., LANCET, vol. 395, 2020, pages 1054 - 62
BHANDARY ET AL., PLOS ONE, vol. 10, 2015, pages e0116504
HUANG WT ET AL., AM J RESPIR CELL MOL BIOL., vol. 46, no. 1, January 2012 (2012-01-01), pages 87
LIU RM ET AL., AM J PHYSIOL LUNG CELL MOL PHYSIOL., vol. 310, 2016, pages L328
KOHARA ET AL., J. MED. CHEM., vol. 39, 1996, pages 5228 - 5235
ASHCROFT T ET AL., J CLIN PATHOL, vol. 41, 1988, pages 467
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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