Title:
DRUGS CONTAINING ROTENOIDS
Document Type and Number:
WIPO Patent Application WO/1998/015269
Kind Code:
A1
Abstract:
Drugs containing as the active ingredient rotenoids represented by general formula (1) wherein R?2� and R?3� represent each hydroxy, C�1-3? alkoxy, etc.; R?8� and R?10� represent each hydrogen, C�1-6? alkyl or C�2-6? alkenyl; R?9� represents hydroxy, C�1-3? alkoxy, etc.; R?11� and R?12a� represent each hydrogen, hydroxy or C�1-3? alkoxy; X represents -C(=O)-, etc.; and Y represents -CH(R)- (wherein R represents hydrogen, hydroxy or C�1-3? alkoxy), etc. These drugs exert antibacterial effects specifically on microorganisms belonging to the genus $i(Helicobacter), such as $i(H. pylori), and are usable in the treatment of gastric ulcer, gastric cancer, etc.
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Inventors:
TAKASHIMA JUNKO (JP)
CHIBA NORIKO (JP)
CHIBA NORIKO (JP)
Application Number:
PCT/JP1997/003587
Publication Date:
April 16, 1998
Filing Date:
October 07, 1997
Export Citation:
Assignee:
MITSUBISHI CHEM CORP (JP)
TAKASHIMA JUNKO (JP)
CHIBA NORIKO (JP)
TAKASHIMA JUNKO (JP)
CHIBA NORIKO (JP)
International Classes:
C07D493/14; (IPC1-7): A61K31/35; C07D493/04
Foreign References:
| JPS60178815A | 1985-09-12 |
Other References:
JOURNAL OF MEDICAL CHEMISTRY, 1980, Vol. 23, ASHACK et al., "Evaluation of Rotenone and Related Compounds as Antagonists of Slow-Reacting Substance of Anaphylaxis", pages 1022-1026.
JOURNAL OF CHEMICAL SOCIETY, PERKIN TRANS. 1, 1991, CROMBIE et al., "Identification and Isotopic Labelling of the Diastereotopic Methyl Group of the Prenyl-Derived 2-Hydroxyisopropyl Residues of Natural Products: The Rotenoid Dalpanol", pages 3143-3148.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1987, Vol. 24, ABIDI et al., "Optical Resolution of Rotenoids", pages 845-852.
JOURNAL OF CHEMICAL SOCIETY, CHEM. COMM., 1979, CROMBIE et al., "Synthesis of (7'-14C)- and (7'-13C)-Rotenone and (4'-14C)- and (4'-13C)-Rot-2'-enoic Acid: 1,4-Allylic Hydrogenolysis Showing Substantial Stereoselectivity", pages 1142-1143.
TETRAHEDRON LETTERS, 1977, KRUPADANUM et al., "New C-6 Oxygenated Rotenoids from Tephrosia Villosa-Villosin, Villosone, Villol and Villinol", pages 2125-2128.
JOURNAL OF CHEMICAL SOCIETY, PERKIN TRANS. 1, 1973, CROMBIE et al., "Biosynthesis of Rotenoids. Chalcone, Isoflavone and Rotenoid Stages in the Formation of Amorphigenin by Amorpha Fruticosa Seedlings", pages 1285-1294.
JOURNAL OF CHEMICAL SOCIETY, PERKIN TRANS. 1, 1991, CROMBIE et al., "Identification and Isotopic Labelling of the Diastereotopic Methyl Group of the Prenyl-Derived 2-Hydroxyisopropyl Residues of Natural Products: The Rotenoid Dalpanol", pages 3143-3148.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1987, Vol. 24, ABIDI et al., "Optical Resolution of Rotenoids", pages 845-852.
JOURNAL OF CHEMICAL SOCIETY, CHEM. COMM., 1979, CROMBIE et al., "Synthesis of (7'-14C)- and (7'-13C)-Rotenone and (4'-14C)- and (4'-13C)-Rot-2'-enoic Acid: 1,4-Allylic Hydrogenolysis Showing Substantial Stereoselectivity", pages 1142-1143.
TETRAHEDRON LETTERS, 1977, KRUPADANUM et al., "New C-6 Oxygenated Rotenoids from Tephrosia Villosa-Villosin, Villosone, Villol and Villinol", pages 2125-2128.
JOURNAL OF CHEMICAL SOCIETY, PERKIN TRANS. 1, 1973, CROMBIE et al., "Biosynthesis of Rotenoids. Chalcone, Isoflavone and Rotenoid Stages in the Formation of Amorphigenin by Amorpha Fruticosa Seedlings", pages 1285-1294.
Attorney, Agent or Firm:
Imamura, Masazumi (5th floor 5-5, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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