DSRNA, USE THEREOF AND PREPARATION METHOD THEREFOR

Title:

DSRNA, USE THEREOF AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2023/138650

Kind Code:

A1

Abstract:

Provided are a dsRNA, a use thereof and a preparation method therefor. Also provided are a pharmaceutical composition comprising the dsRNA, a cell or a kit. The dsRNA can interfere with the expression of HSD17B13 to prevent and/or treat related diseases.

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Inventors:

LIN XIAOYAN (CN)
DONG YUQIONG (CN)
ZHANG ZHEN (CN)
LI YUNFEI (CN)
WANG YANHUI (CN)
MAO SONG (CN)
ZHOU YAQIN (CN)
HUANG LONGFEI (CN)
HUANG YANFEN (CN)
HUANG MINYIN (CN)

Application Number:

PCT/CN2023/073096

Publication Date:

July 27, 2023

Filing Date:

January 19, 2023

Export Citation:

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Assignee:

TUOJIE BIOTECH SHANGHAI CO LTD (CN)

International Classes:

C12N15/113; A61K31/713; A61K48/00; A61P1/16

Foreign References:

CN112020556A	2020-12-01
CN112423794A	2021-02-26
CN113164509A	2021-07-23
CN113544272A	2021-10-22

Other References:

KUMAR SANTOSH; DUAN QIHUA; WU RONGXUE; HARRIS EDWARD N.; SU QIAOZHU: "Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM , NL, vol. 176, 16 July 2021 (2021-07-16), Amsterdam , NL , XP086773674, ISSN: 0169-409X, DOI: 10.1016/j.addr.2021.113869

Attorney, Agent or Firm:

GE CHENG & CO., LTD. (CN)

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