Title:
RATIONALLY DESIGNED SINGLE-ROUND INFECTIOUS VIRUS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/138651
Kind Code:
A1
Abstract:
Provided are engineered, replication-deficient influenza viruses that are infectious and stimulate broadly-cross protective immunity against multiple different influenza strains. Also provided are compositions and methods for providing protective immune responses against influenza. The methods deliver compositions of intact, replication-deficient influenza viruses by intradermal administration in an amount effective to elicit or stimulate a cross-protective immune response to influenza viruses in the recipient following a single administration. Because the engineered influenza viruses are non-replicating, they are safe and effective in immunocompromised subjects. Also provided are methods for delivering co-stimulatory molecules, growth factors, adjuvants and/ or cytokines together with the non-replicating influenza viruses.
Inventors:
KOK KIN HANG (CN)
YUEN CHUN KIT (CN)
YUEN KWOK YUNG (CN)
WONG WAN MAN (CN)
YUEN CHUN KIT (CN)
YUEN KWOK YUNG (CN)
WONG WAN MAN (CN)
Application Number:
PCT/CN2023/073098
Publication Date:
July 27, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
VERSITECH LTD (CN)
CENTRE FOR VIROLOGY VACCINOLOGY AND THERAPEUTICS LTD (CN)
CENTRE FOR VIROLOGY VACCINOLOGY AND THERAPEUTICS LTD (CN)
International Classes:
C12N7/04; A61K39/145; A61P31/16
Foreign References:
| CN113755456A | 2021-12-07 | |||
| CN102586199A | 2012-07-18 | |||
| US20080292658A1 | 2008-11-27 |
Other References:
YAMAGATA YUTARO, MURAMOTO YUKIKO, MIYAMOTO SHO, SHINDO KEIKO, NAKANO MASAHIRO, NODA TAKESHI: "Generation of a purely clonal defective interfering influenza virus", MICROBIOLOGY AND IMMUNOLOGY, CENTER FOR ACADEMIC PUBLICATIONS JAPAN|, JP, vol. 63, no. 5, 1 May 2019 (2019-05-01), JP , pages 164 - 171, XP093080085, ISSN: 0385-5600, DOI: 10.1111/1348-0421.12681
YANG PENG-HUI ET AL.: "Generation of cold-adapted reassortant live influenza A virus by reverse genetics", IMMUNOLOGICAL JOURNAL, vol. 23, no. 3, 15 May 2007 (2007-05-15), XP009547867, ISSN: 1000-8861
YANG PENG-HUI ET AL.: "Generation of cold-adapted reassortant live influenza A virus by reverse genetics", IMMUNOLOGICAL JOURNAL, vol. 23, no. 3, 15 May 2007 (2007-05-15), XP009547867, ISSN: 1000-8861
Attorney, Agent or Firm:
LIU , SHEN & ASSOCIATES (CN)
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