DYE-SULFENATES FOR DUAL PHOTOTHERAPY

Title:

DYE-SULFENATES FOR DUAL PHOTOTHERAPY

Document Type and Number:

WIPO Patent Application WO2003004466

Kind Code:

A3

Abstract:

The present invention discloses dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds of the present invention may contain either a mixture of type 1 and type 2 agents or a single entity that integrates both units in the same molecules. The compounds are designed to produce both type 1 and type 2 phototherapeutic effect at once using dual wavelength light source that will produce singlet oxygen and free radicals at the lesion of interest.

Inventors:

RAJAGOPALAN RAGHAVAN (US)
ACHILEFU SAMUEL I (US)
BUGAJ JOSEPH E (US)
DORSHOW RICHARD B (US)

Application Number:

PCT/US2002/019184

Publication Date:

March 20, 2003

Filing Date:

June 18, 2002

Export Citation:

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Assignee:

MALLINCKRODT INC (US)
RAJAGOPALAN RAGHAVAN (US)
ACHILEFU SAMUEL I (US)
BUGAJ JOSEPH E (US)
DORSHOW RICHARD B (US)

International Classes:

A61K41/00; A61K47/48; C07H15/26; A61K49/00; A61K49/04; A61P35/00; A61P43/00; C07D209/12; C07D209/60; C07D405/12; C07K7/06; C07K14/575; C09B23/00; C09B23/01; C09B23/08; (IPC1-7): C07D403/14; C07D487/22

Foreign References:

US6217848B1	2001-04-17
US6395257B1	2002-05-28

Other References: