Title:
THIAZOLE BENZAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION, AND METHODS FOR THEIR USE
Document Type and Number:
WIPO Patent Application WO2003004467
Kind Code:
A3
Abstract:
Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.
Inventors:
CHU SHAO SONG (US)
ALEGRIA LARRY ANDREW (US)
BLECKMAN TED MICHAEL (US)
CHONG WESLEY K M (US)
DUVADIE ROHIT K (US)
LI LIN (US)
REICH SIEGFRIED H (US)
ROMINES WILLIAM H (US)
WALLACE MICHAEL B (US)
YANG YI (US)
ALEGRIA LARRY ANDREW (US)
BLECKMAN TED MICHAEL (US)
CHONG WESLEY K M (US)
DUVADIE ROHIT K (US)
LI LIN (US)
REICH SIEGFRIED H (US)
ROMINES WILLIAM H (US)
WALLACE MICHAEL B (US)
YANG YI (US)
Application Number:
PCT/US2002/021280
Publication Date:
May 06, 2004
Filing Date:
July 05, 2002
Export Citation:
Assignee:
AGOURON PHARMA (US)
CHU SHAO SONG (US)
ALEGRIA LARRY ANDREW (US)
BLECKMAN TED MICHAEL (US)
CHONG WESLEY K M (US)
DUVADIE ROHIT K (US)
LI LIN (US)
REICH SIEGFRIED H (US)
ROMINES WILLIAM H (US)
WALLACE MICHAEL B (US)
YANG YI (US)
CHU SHAO SONG (US)
ALEGRIA LARRY ANDREW (US)
BLECKMAN TED MICHAEL (US)
CHONG WESLEY K M (US)
DUVADIE ROHIT K (US)
LI LIN (US)
REICH SIEGFRIED H (US)
ROMINES WILLIAM H (US)
WALLACE MICHAEL B (US)
YANG YI (US)
International Classes:
A61K31/426; A61K31/427; C07D277/62; A61K31/428; A61K31/438; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61P1/04; A61P1/16; A61P3/10; A61P7/06; A61P9/00; A61P9/06; A61P9/10; A61P11/00; A61P13/08; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/02; A61P31/10; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P35/04; A61P37/00; A61P37/02; A61P37/04; A61P37/06; A61P43/00; C07D277/20; C07D277/38; C07D277/42; C07D277/44; C07D277/56; C07D417/06; C07D417/12; C07D417/14; C07D491/10; C07D491/20; C07D521/00; (IPC1-7): A61K31/425; C07D277/56
Domestic Patent References:
| WO1999021845A2 | 1999-05-06 |
Other References:
See also references of EP 1438046A4
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