Title:
DYNAMIC ANTIBACTERIAL HYDROGEL BASED ON NATURAL RECEPTOR LIGAND RECOGNITION EFFECT, PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2023/216495
Kind Code:
A1
Abstract:
Provided are a dynamic antibacterial hydrogel based on a natural receptor ligand recognition effect, a preparation method and use, which belong to the field of biomedical materials. First, a modification material is used to modify the ligand vancomycin and a receptor AA-based material, then a photoinitiator is added, and a hydrogel material is obtained under ultraviolet irradiation. The hydrogel undergoes cross-linking to form a three-dimensional network structure. After the hydrogel breaks under external pressure, it rapidly undergoes cross-linking and self-heals due to interactions between the ligand and the receptor and multiple hydrogen bond interactions. The healing mimics natural ligand-receptor interactions and the dynamic properties of the hydrogel material are achieved. The efficient sterilization ability of vancomycin shows the functionality of the hydrogel material. The monomer of physiological origin improves its biocompatibility and reduces biotoxicity. With the combination of the dynamic properties, functionality and biological properties, the hydrogel applies for antibacterial and bacteriostatic purposes and to skin repair.
Inventors:
PAN GUOQING (CN)
HE WENBO (CN)
MA YUE (CN)
WANG MIAO (CN)
HE WENBO (CN)
MA YUE (CN)
WANG MIAO (CN)
Application Number:
PCT/CN2022/121661
Publication Date:
November 16, 2023
Filing Date:
September 27, 2022
Export Citation:
Assignee:
UNIV JIANGSU (CN)
International Classes:
C08F299/02; A61L26/00; C08J3/075; C08L53/00
Foreign References:
| CN101431983A | 2009-05-13 | |||
| US20130017232A1 | 2013-01-17 | |||
| CN110917392A | 2020-03-27 | |||
| CN113018417A | 2021-06-25 |
Other References:
LAWSON MCKINLEY C., SHOEMAKER RICHARD, HOTH KEVIN B., BOWMAN CHRISTOPHER N., ANSETH KRISTI S.: "Polymerizable Vancomycin Derivatives for Bactericidal Biomaterial Surface Modification: Structure−Function Evaluation", BIOMACROMOLECULES, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 8, 10 August 2009 (2009-08-10), US , pages 2221 - 2234, XP093107388, ISSN: 1525-7797, DOI: 10.1021/bm900410a
MCKINLEY C LAWSON, CHRISTOPHER N BOWMAN, KRISTI S ANSETH: "Vancomycin Derivative Photopolymerized to Titanium Kills S. Epidermidis", CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, SPRINGER NEW YORK LLC, US, no. 461, 31 August 2007 (2007-08-31), US , pages 96 - 105, XP009550290, ISSN: 0009-921X, DOI: 10.1097/BLO.0b013e3180986706.
MCKINLEY C LAWSON, CHRISTOPHER N BOWMAN, KRISTI S ANSETH: "Vancomycin Derivative Photopolymerized to Titanium Kills S. Epidermidis", CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, SPRINGER NEW YORK LLC, US, no. 461, 31 August 2007 (2007-08-31), US , pages 96 - 105, XP009550290, ISSN: 0009-921X, DOI: 10.1097/BLO.0b013e3180986706.
Attorney, Agent or Firm:
NANJING DOYES INTELLECTUAL PROPERTY CO., LTD. (CN)
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