Title:
AN EFFICIENT METHOD FOR PREPARATION OF (S)-3-[(1-DIMETHYL AMINO)ETHYL]-PHENYL-N-ETHYL-N-METHYL-CARBAMATE
Document Type and Number:
WIPO Patent Application WO2006048720
Kind Code:
B1
Abstract:
The present invention relates to a method for preparation of substituted phenyl carbamate and pharmaceutically acceptable salts thereof, which are of current pharmaceutical interest. The substituted phenyl carbamate and pharmaceutically acceptable salts thereof are useful to raise cholinergic activity in the central nervous system and useful in treatment of diseases such as Alzheimer's disease, Down's syndrome, Huntingdon's chorea, Friedrich's ataxia etc. (S)-3-[(1-dimethyl amino)ethyl]- phenyl-N-ethyl-N-methyl-carbamate (I) is the active ingredient of the pharmaceutical composition referred in US 5,602,176. This compound is also used to induce selective inhibition of acetylcholinesterase activity in the brain.
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Inventors:
GHARPURE MILIND MORESHWAR (IN)
BHAWAL BABURAO MANIKRAO (IN)
SHAH VIRAL BIPINBHAI (IN)
ZOPE UMESH REWAJI (IN)
MEHTA SATISH RAMANLAL (IN)
BHAWAL BABURAO MANIKRAO (IN)
SHAH VIRAL BIPINBHAI (IN)
ZOPE UMESH REWAJI (IN)
MEHTA SATISH RAMANLAL (IN)
Application Number:
PCT/IB2005/003237
Publication Date:
July 06, 2006
Filing Date:
October 29, 2005
Export Citation:
Assignee:
EMCURE PHARMACEUTICALS LTD (IN)
GHARPURE MILIND MORESHWAR (IN)
BHAWAL BABURAO MANIKRAO (IN)
SHAH VIRAL BIPINBHAI (IN)
ZOPE UMESH REWAJI (IN)
MEHTA SATISH RAMANLAL (IN)
GHARPURE MILIND MORESHWAR (IN)
BHAWAL BABURAO MANIKRAO (IN)
SHAH VIRAL BIPINBHAI (IN)
ZOPE UMESH REWAJI (IN)
MEHTA SATISH RAMANLAL (IN)
International Classes:
C07C269/04; C07C269/00; C07C271/44
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