Title:
EMBOLIC AGENT AND BLOOD VESSEL EMBOLIZATION KIT
Document Type and Number:
WIPO Patent Application WO/2023/163170
Kind Code:
A1
Abstract:
The embolic agent according to the present invention is a copolymer formed from a cationic functional group-containing monomer and an aromatic group-containing monomer, said embolic agent having, as an active ingredient, a copolymer which at least partly has a structure expressed by general formula (I) (In the formula, R11 and R12 represent a hydrogen atom or an alkyl group, which has 1 to 20 carbon atoms and may have a substituent, and satisfy the relational expression R11=R12. Y11 and Y12 independently represent a single bond or an alkylene group which has 1 to 20 carbon atoms. Ar11 represents an aromatic hydrocarbon group which has 6 to 16 carbon atoms and may have a substituent. X11 represents an ammonium group or an amino group. n11 represents an integer of 10 to 1,000.)
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Inventors:
FAN HAILONG (JP)
OSANAI TOSHIYA (JP)
JIN ZHIPING (JP)
KUROKAWA TAKAYUKI (JP)
NONOYAMA TAKAYUKI (JP)
OSANAI TOSHIYA (JP)
JIN ZHIPING (JP)
KUROKAWA TAKAYUKI (JP)
NONOYAMA TAKAYUKI (JP)
Application Number:
PCT/JP2023/007042
Publication Date:
August 31, 2023
Filing Date:
February 27, 2023
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61L31/04; A61L31/12; A61L31/14; A61P7/04; A61P9/00; A61P35/00; C08F220/10
Foreign References:
| CN110559470A | 2019-12-13 | |||
| JP2000506514A | 2000-05-30 | |||
| JPH05253283A | 1993-10-05 | |||
| JPH0557014A | 1993-03-09 | |||
| CN104130348A | 2014-11-05 |
Other References:
LIANG RUIXUE, YU HAOJIE, WANG LI, LIN LONG, WANG NAN, NAVEED KALEEM-UR-RAHMAN: "Highly Tough Hydrogels with the Body Temperature-Responsive Shape Memory Effect", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 11, no. 46, 20 November 2019 (2019-11-20), US , pages 43563 - 43572, XP093087647, ISSN: 1944-8244, DOI: 10.1021/acsami.9b14756
FAN HAILONG, WANG JIAHUI, TAO ZHEN, HUANG JUNCHAO, RAO PING, KUROKAWA TAKAYUKI, GONG JIAN PING: "Adjacent cationic–aromatic sequences yield strong electrostatic adhesion of hydrogels in seawater", NATURE COMMUNICATIONS, vol. 10, no. 1, 12 November 2019 (2019-11-12), pages 5127, XP093087648, DOI: 10.1038/s41467-019-13171-9
TAMURA GOICHIRO, KATO NORIYUKI, YAMAZAKI TOMOSATO, AKUTSU YOSHIMITSU, HOSOO HISAYUKI, KASUYA HIROMICHI, SONOBE MAKOTO: "Endovascular Embolization of Brain Arteriovenous Malformations with Eudragit-E", NEUROLOGIA MEDICO-CHIRURGICA, vol. 55, no. 3, 1 January 2015 (2015-01-01), pages 253 - 260, XP093087650, ISSN: 0470-8105, DOI: 10.2176/nmc.oa.2014-0287
FAN HAILONG, WANG JIAHUI, TAO ZHEN, HUANG JUNCHAO, RAO PING, KUROKAWA TAKAYUKI, GONG JIAN PING: "Adjacent cationic–aromatic sequences yield strong electrostatic adhesion of hydrogels in seawater", NATURE COMMUNICATIONS, vol. 10, no. 1, 12 November 2019 (2019-11-12), pages 5127, XP093087648, DOI: 10.1038/s41467-019-13171-9
TAMURA GOICHIRO, KATO NORIYUKI, YAMAZAKI TOMOSATO, AKUTSU YOSHIMITSU, HOSOO HISAYUKI, KASUYA HIROMICHI, SONOBE MAKOTO: "Endovascular Embolization of Brain Arteriovenous Malformations with Eudragit-E", NEUROLOGIA MEDICO-CHIRURGICA, vol. 55, no. 3, 1 January 2015 (2015-01-01), pages 253 - 260, XP093087650, ISSN: 0470-8105, DOI: 10.2176/nmc.oa.2014-0287
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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