Title:
ENHANCER OF FERTILIZATION FUNCTION OF SPERM
Document Type and Number:
WIPO Patent Application WO/2019/235455
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: an enhancer of the fertilization function of a mammal sperm, which contains a low-molecular-weight compound that can be produced in a relatively simple manner and at relatively low cost as an active ingredient; a method for enhancing the fertilization function of a mammal sperm using a low-molecular-weight compound that can be produced in a relatively simple manner and at relatively low cost; and a method for producing a mammal fertilized egg. An enhancer of the fertilization function of a mammal sperm comprises at least one compound selected from the group consisting of compounds respectively represented by general formula (I0), general formula (II) and general formula (III) and physiologically acceptable salts thereof in each of which R3 represents OH.
Inventors:
ABE TAKAAKI (JP)
YAEGASHI NOBUO (JP)
TACHIBANA MASAHITO (JP)
HAYASHI KENICHIRO (JP)
YAEGASHI NOBUO (JP)
TACHIBANA MASAHITO (JP)
HAYASHI KENICHIRO (JP)
Application Number:
PCT/JP2019/022082
Publication Date:
December 12, 2019
Filing Date:
June 04, 2019
Export Citation:
Assignee:
UNIV TOHOKU (JP)
KAKE EDUCATIONAL INST (JP)
KAKE EDUCATIONAL INST (JP)
International Classes:
A61K31/405; A61P15/00; A61P43/00; C12N5/076
Domestic Patent References:
| WO2017072816A1 | 2017-05-04 | |||
| WO2017072984A1 | 2017-05-04 | |||
| WO2017073060A1 | 2017-05-04 | |||
| WO2014080640A1 | 2014-05-30 |
Foreign References:
| JP2018076274A | 2018-05-17 |
Other References:
SUZUKI TAKEHIRO ET AL.: "Mitochonic acid 5 (MA-5), a derivative of the plant hormone indole-3-acetic acid, improves survival of fibroblasts from patients with mitochondrial diseases", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol. 236, no. 3, 2015, pages 225 - 232, XP055379205, DOI: 10.1620/tjem.236.225
HAYASHI KEN-ICHIRO ET AL.: "Rational Design of an Auxin Antagonist of the SCFTIR1 Auxin Receptor Complex", ACS CHEMICAL BIOLOGY, vol. 7, no. 3, 16 March 2012 (2012-03-16), pages 590 - 598, XP055287676
HAYASHI KEN-ICHIRO ET AL.: "Rational Design of an Auxin Antagonist of the SCFTIR1 Auxin Receptor Complex", ACS CHEMICAL BIOLOGY, vol. 7, no. 3, 16 March 2012 (2012-03-16), pages 590 - 598, XP055287676
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
Download PDF: