Title:
ENZYMES INVOLVED IN APOPTOSIS
Document Type and Number:
WIPO Patent Application WO2004078783
Kind Code:
A3
Abstract:
The present invention relates to a method of identifying an agent that modulates the function of an apoptosis-associated polypeptide having a sequence as set out in Table 1, the method comprising: (a) providing a sample containing an apoptosis-associated polypeptide having a sequence as set out in Table 1, and a candidate agent and incubating under conditions to permit binding of the candidate agent to the polypeptide; (b) measuring the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1 to the candidate agent in the sample; and (c) comparing the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1 to the candidate agent in the sample with the binding of the polypeptide having a sequence as set out in Table 1 to a control agent, wherein the control agent is known to not bind to the polypeptide having a sequence as set out in Table 1; wherein an increase in the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1 to the candidate agent in the sample relative to the binding of the apoptosis-associated polypeptide having a sequence as set out in Table 1 to the control agent indicates that the candidate agent modulates the function of the apoptosis-associated polypeptide having a sequence as set out in Table 1.
Inventors:
MURPHY FINBARR J (IE)
SHEEHAN DYAN E (IE)
KEATING KATHERINE E (IE)
HAYES IAN (IE)
SEERA LIAM (IE)
SHEEHAN DYAN E (IE)
KEATING KATHERINE E (IE)
HAYES IAN (IE)
SEERA LIAM (IE)
Application Number:
PCT/GB2004/000957
Publication Date:
January 20, 2005
Filing Date:
March 05, 2004
Export Citation:
Assignee:
EIRX THERAPEUTICS LTD (IE)
MURPHY FINBARR J (IE)
SHEEHAN DYAN E (IE)
KEATING KATHERINE E (IE)
HAYES IAN (IE)
SEERA LIAM (IE)
MURPHY FINBARR J (IE)
SHEEHAN DYAN E (IE)
KEATING KATHERINE E (IE)
HAYES IAN (IE)
SEERA LIAM (IE)
International Classes:
C07K14/47; A61K38/00; (IPC1-7): C07K14/47; C12N5/10; C12N15/11; C12Q1/68; G01N33/50
Domestic Patent References:
| WO2000056752A2 | 2000-09-28 | |||
| WO2002004657A2 | 2002-01-17 | |||
| WO2003072035A2 | 2003-09-04 | |||
| WO2003087768A2 | 2003-10-23 |
Foreign References:
| US20020192745A1 | 2002-12-19 |
Other References:
DATABASE GENBANK 2 November 2000 (2000-11-02), "Homo sapiens RNA helicase (RIG-I), mRNA", XP002290438, retrieved from NCBI Database accession no. NM_014314
KANNAN KARUPPIAH ET AL: "DNA microarray analysis of genes involved in p53 mediated apoptosis: Activation of Apaf-1", ONCOGENE, vol. 20, no. 26, 7 June 2001 (2001-06-07), pages 3449 - 3455, XP002290437, ISSN: 0950-9232
KANNAN KARUPPIAH ET AL: "DNA microarray analysis of genes involved in p53 mediated apoptosis: Activation of Apaf-1", ONCOGENE, vol. 20, no. 26, 7 June 2001 (2001-06-07), pages 3449 - 3455, XP002290437, ISSN: 0950-9232
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