Title:
EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS
Document Type and Number:
WIPO Patent Application WO2002032422
Kind Code:
A3
Abstract:
The invention features a method of treating rheumatoid arthritis in a mammal comprising administering an agent that inhibits prostaglandin EP4 receptor (EP4) activity. Also featured is a method of identifying agents that selectively inhibit EP4 activity in vivo.
Inventors:
AUDOLY LAURENT (US)
OKUMURA TAKAKO (JP)
SHIMOJO MASATO (JP)
OKUMURA TAKAKO (JP)
SHIMOJO MASATO (JP)
Application Number:
PCT/IB2001/001942
Publication Date:
July 25, 2002
Filing Date:
October 15, 2001
Export Citation:
Assignee:
PFIZER PHARMA (JP)
PFIZER (US)
AUDOLY LAURENT (US)
OKUMURA TAKAKO (JP)
SHIMOJO MASATO (JP)
PFIZER (US)
AUDOLY LAURENT (US)
OKUMURA TAKAKO (JP)
SHIMOJO MASATO (JP)
International Classes:
G01N33/48; A61K31/00; A61K31/4178; A61K31/4184; A61K31/4188; A61K31/427; A61K31/437; A61K31/4439; A61K31/444; A61K31/454; A61K31/4725; A61K31/506; A61K31/52; A61K31/64; A61K45/00; A61P1/00; A61P1/02; A61P1/04; A61P3/10; A61P5/00; A61P7/02; A61P7/04; A61P7/08; A61P9/00; A61P9/10; A61P9/12; A61P9/14; A61P11/02; A61P11/06; A61P13/12; A61P15/04; A61P15/06; A61P17/00; A61P17/02; A61P17/16; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/20; A61P25/28; A61P27/00; A61P27/06; A61P29/00; A61P31/12; A61P31/16; A61P31/18; A61P35/00; A61P35/04; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P41/00; A61P43/00; C07D235/06; C07D235/08; C07D235/12; C07D235/14; C07D235/16; C07D235/30; C07D401/04; C07D401/06; C07D401/12; C07D403/04; C07D403/06; C07D403/12; C07D413/12; C07D417/04; C07D417/12; C07D471/04; C07D473/00; C07D491/04; C07D491/048; C07D491/056; C07D521/00; G01N33/15; G01N33/50; C07D235/10; (IPC1-7): A61K31/4178; A61K31/437; A61P29/00; A61K31/64
Domestic Patent References:
| WO2000021542A1 | 2000-04-20 | |||
| WO2000021532A1 | 2000-04-20 | |||
| WO1999047497A2 | 1999-09-23 |
Foreign References:
| GB2330307A | 1999-04-21 |
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