Title:
INDOLE COMPOUNDS AS MINIMALLY PHYSIOLOGIAL FUNCTION MONITIORING AGENTS
Document Type and Number:
WIPO Patent Application WO2002032421
Kind Code:
A8
Abstract:
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
Inventors:
ACHILEFU SAMUEL (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
Application Number:
PCT/US2001/031719
Publication Date:
September 06, 2002
Filing Date:
October 05, 2001
Export Citation:
Assignee:
MALLINCKRODT INC (US)
ACHILEFU SAMUEL (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
ACHILEFU SAMUEL (US)
RAJAGOPALAN RAGHAVAN (US)
DORSHOW RICHARD B (US)
BUGAJ JOSEPH E (US)
International Classes:
A61K49/00; A61K31/405; C07D209/18; C07D209/24; C07D209/60; C09B23/01; C09B23/08; (IPC1-7): A61K31/405; C07D403/08
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