Title:
EPIDERMAL STEM CELL PROLIFERATION-PROMOTING AGENT
Document Type and Number:
WIPO Patent Application WO/2022/131182
Kind Code:
A1
Abstract:
The present disclosure pertains to provision of a composition that is effective in improving conditions of skin in terms of maintenance and improvement of quality of life (QOL) related to both health and beauty. More specifically, the present disclosure pertains to a composition containing 1-(2-hydroxyethyl)-2-imidazolidinone or a derivative thereof, and a pyridine carboxamide. This promotes the proliferation of epidermal stem cells and the proliferation of keratinocytes, and therefore, can be suitably used as a cosmetic composition such as a cosmetic that is effective in improving conditions of skin.
Inventors:
TOBITA RYOZO (JP)
IRIYAMA SHUNSUKE (JP)
YAMADA MINAMI (JP)
IRIYAMA SHUNSUKE (JP)
YAMADA MINAMI (JP)
Application Number:
PCT/JP2021/045725
Publication Date:
June 23, 2022
Filing Date:
December 13, 2021
Export Citation:
Assignee:
SHISEIDO CO LTD (JP)
International Classes:
A61K8/49; A61Q19/00; A61Q19/08; C12N15/09
Domestic Patent References:
| WO2019078370A1 | 2019-04-25 |
Foreign References:
| JP2011184308A | 2011-09-22 | |||
| JP2014111640A | 2014-06-19 | |||
| JP2005298370A | 2005-10-27 | |||
| JP2014111640A | 2014-06-19 | |||
| JP2014165586A | 2014-09-08 | |||
| JP2018545781A | 2017-10-20 |
Other References:
VLODAVSKY I., SEMIN CANCER BIOL., vol. 12, no. 2, 2002, pages 121 - 129
PAN W, MIAO HQ, XU YJ, NAVARRO EC, TONRA JR, CORCORAN E: "1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol -2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 2, 2006, pages 409 - 12, XP025106541, DOI: 10.1016/j.bmcl.2005.09.069
MACPHERSON LJBAYBURT EKCAPPARELLI MPCARROLL BJGOLDSTEIN RJUSTICE MR ET AL.: "Discovery of CGS 27023A, a non- peptidic , potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits", JOURNAL OF MEDICINAL, vol. 40, no. 16, 1997, pages 2525 - 32, XP002942148, DOI: 10.1021/jm960871c
IRIYAMA S, YAMANISHI H, KUNIZAWA N, HIRAO T, AMANO S: "1-(2-hydroxyethyl)-2-imidazolidinone, a heparanase and matrix metalloproteinase inhibitor, improves epidermal basement membrane structure and epidermal barrier function", EXPERIMENTAL DERMATOLOGY, vol. 28, no. 3, 2019, pages 247 - 53, XP055688084, DOI: 10.1111/exd.13876
IRIYAMA SYASUDA MNISHIKAWA STAKAI EHOSOI JAMANO S: "Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem/progenitor cells", SCIENTIFIC REPORTS, vol. 10, no. 1, 2020, pages 12592
PAN W, MIAO HQ, XU YJ, NAVARRO EC, TONRA JR, CORCORAN E: "1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol -2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 2, 2006, pages 409 - 12, XP025106541, DOI: 10.1016/j.bmcl.2005.09.069
MACPHERSON LJBAYBURT EKCAPPARELLI MPCARROLL BJGOLDSTEIN RJUSTICE MR ET AL.: "Discovery of CGS 27023A, a non- peptidic , potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits", JOURNAL OF MEDICINAL, vol. 40, no. 16, 1997, pages 2525 - 32, XP002942148, DOI: 10.1021/jm960871c
IRIYAMA S, YAMANISHI H, KUNIZAWA N, HIRAO T, AMANO S: "1-(2-hydroxyethyl)-2-imidazolidinone, a heparanase and matrix metalloproteinase inhibitor, improves epidermal basement membrane structure and epidermal barrier function", EXPERIMENTAL DERMATOLOGY, vol. 28, no. 3, 2019, pages 247 - 53, XP055688084, DOI: 10.1111/exd.13876
IRIYAMA SYASUDA MNISHIKAWA STAKAI EHOSOI JAMANO S: "Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal stem/progenitor cells", SCIENTIFIC REPORTS, vol. 10, no. 1, 2020, pages 12592
Attorney, Agent or Firm:
ITO Katsuhiro et al. (JP)
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