ESTER TO AMIDE CONVERSION CATALYST USING OXIME-HYDROXYAMINE AS SUBSTRATE

Title:

ESTER TO AMIDE CONVERSION CATALYST USING OXIME-HYDROXYAMINE AS SUBSTRATE

Document Type and Number:

WIPO Patent Application WO/2018/199146

Kind Code:

A1

Abstract:

Provided is a novel method for producing amide compounds at high stereochemical selectivity. This method for producing amide compounds is provided with an amidation step for reacting an aminoester compound represented by general formula (1) and an amino compound in the presence of a catalyst comprising a metal compound to amidate the ester groups of the aminoester compound.

Inventors:

YAMAMOTO HISASHI (JP)
MURAMATSU WATARU (JP)
TSUJI HIROAKI (JP)
KODAMA HIDEHIKO (JP)
AKAI YUTO (JP)

Application Number:

PCT/JP2018/016766

Publication Date:

November 01, 2018

Filing Date:

April 25, 2018

Export Citation:

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Assignee:

CHUBU UNIV EDUCATIONAL FOUNDATION (JP)
NIPPON PHARMACEUTICAL CHEMICALS CO LTD (JP)

International Classes:

C07C249/12; C07C231/12; C07C237/12; C07C239/08; C07C251/38; C07C319/20; C07C321/14; C07D207/16; C07D209/20; C07B61/00

Domestic Patent References:

WO2009060843A1

2009-05-14

Foreign References:

CN103265616A	2013-08-28
JPH05163224A	1993-06-29
JP2005015465A	2005-01-20
JP2010521453A	2010-06-24

Other References:

TSUJI, HIROAKI ET AL.: "Hydroxy-Directed Amidation of Carboxylie Acid Esters Using a Tantalum Alkoxide Catalyst", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 43, 21 October 2016 (2016-10-21), pages 14218 - 14221, XP055527397
MURAMATSU, WATARU ET AL.: "Catalytic Peptide Synthesis: Amidation of N-Hydroxyimino Esters", ACS CATALYSIS, vol. 8, no. 3, 7 February 2018 (2018-02-07), pages 2181 - 2187, XP055527402

Attorney, Agent or Firm:

TANAKA, Junya et al. (JP)

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