Title:
EXOSOME PLATFORM-BASED ANTIVIRAL VACCINE
Document Type and Number:
WIPO Patent Application WO/2022/231116
Kind Code:
A1
Abstract:
The present invention relates to an exosome platform-based antiviral vaccine, which can induce a strong immune response to viruses and induce a stable and long-term immune response even to viruses with frequent mutations, so as to be utilized effectively for the purpose of antiviral vaccines.
Inventors:
KIM JAE YOUNG (KR)
CHWAE YONG JOON (KR)
MUSTAJAB TAMANNA (KR)
CHWAE YONG JOON (KR)
MUSTAJAB TAMANNA (KR)
Application Number:
PCT/KR2022/003331
Publication Date:
November 03, 2022
Filing Date:
March 10, 2022
Export Citation:
Assignee:
CK EXOGENE CO LTD (KR)
International Classes:
C07K14/005; A61K39/215; A61P31/14; C07K14/36; C12N15/85
Foreign References:
| CN111647557A | 2020-09-11 |
Other References:
POLAK K., GREZE N., LACHAT M., MERLE D., CHIUMENTO S., BERTRAND-GADAY C., TRENTIN B., MAMOUN R. Z.: "Extracellular vesicle-based vaccine platform displaying native viral envelope proteins elicits a robust anti-SARS-CoV-2 response in mice", BIORXIV, 28 October 2020 (2020-10-28), XP055785135, Retrieved from the Internet [retrieved on 20210312], DOI: 10.1101/2020.10.28.357137
"Master's thesis", 1 February 2020, AJOU UNIVERSITY GRADUATE SCHOOL, Korea, article HUR, JAEHARK: "Roles of gasdermin family in the biogenesis of apoptotic cell-derived exosomes", pages: 1 - 52, XP009540803
KUATE, S. CINATL, J. DOERR, H.W. UBERLA, K.: "Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 362, no. 1, 25 April 2007 (2007-04-25), AMSTERDAM, NL , pages 26 - 37, XP022046488, ISSN: 0042-6822, DOI: 10.1016/j.virol.2006.12.011
EL-SHENNAWY LAMIAA, HOFFMANN ANDREW D., DASHZEVEG NURMAA K., MEHL PAUL J., YU ZIHAO, TOKARS VALERIE L., NICOLAESCU VLAD, OSTIGUIN : "Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Infection as an Innate Antiviral Mechanism", BIORXIV, 4 December 2020 (2020-12-04), XP055958450, [retrieved on 20220907], DOI: 10.1101/2020.12.03.407031
"Master's thesis", 1 February 2020, AJOU UNIVERSITY GRADUATE SCHOOL, Korea, article HUR, JAEHARK: "Roles of gasdermin family in the biogenesis of apoptotic cell-derived exosomes", pages: 1 - 52, XP009540803
KUATE, S. CINATL, J. DOERR, H.W. UBERLA, K.: "Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 362, no. 1, 25 April 2007 (2007-04-25), AMSTERDAM, NL , pages 26 - 37, XP022046488, ISSN: 0042-6822, DOI: 10.1016/j.virol.2006.12.011
EL-SHENNAWY LAMIAA, HOFFMANN ANDREW D., DASHZEVEG NURMAA K., MEHL PAUL J., YU ZIHAO, TOKARS VALERIE L., NICOLAESCU VLAD, OSTIGUIN : "Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Infection as an Innate Antiviral Mechanism", BIORXIV, 4 December 2020 (2020-12-04), XP055958450, [retrieved on 20220907], DOI: 10.1101/2020.12.03.407031
Attorney, Agent or Firm:
SHIM, Kyoung-Shik et al. (KR)
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