Title:
EXPORT AND MODIFICATION OF (POLY)PEPTIDES IN THE LANTIBIOTIC WAY
Document Type and Number:
WIPO Patent Application WO2003099862
Kind Code:
A8
Abstract:
The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.
Inventors:
MOLL GERT NIKOLAAS (NL)
LEENHOUTS CORNELIS JOHANNES (NL)
KUIPERS OSCAR PAUL (NL)
DRIESSEN ARNOLD JACOB MATHIEU (NL)
LEENHOUTS CORNELIS JOHANNES (NL)
KUIPERS OSCAR PAUL (NL)
DRIESSEN ARNOLD JACOB MATHIEU (NL)
Application Number:
PCT/NL2003/000389
Publication Date:
March 11, 2004
Filing Date:
May 26, 2003
Export Citation:
Assignee:
APPLIED NANOSYSTEMS BV (NL)
MOLL GERT NIKOLAAS (NL)
LEENHOUTS CORNELIS JOHANNES (NL)
KUIPERS OSCAR PAUL (NL)
DRIESSEN ARNOLD JACOB MATHIEU (NL)
MOLL GERT NIKOLAAS (NL)
LEENHOUTS CORNELIS JOHANNES (NL)
KUIPERS OSCAR PAUL (NL)
DRIESSEN ARNOLD JACOB MATHIEU (NL)
International Classes:
A61K38/14; C07K9/00; C07K14/315; C12N5/06; C12P21/02; (IPC1-7): C07K14/315
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